硝苯地平联合硫酸镁对子痫前期患者HLA⁃G、HCY水平的影响  

The effect of nifedipine combined with magnesium sulfate on HLA⁃G and HCY levels in patients with preeclampsia

作　　者：熊杰 曹文芳[1] 胡小娜 郭敏 刘莉 Xiong Jie;Cao Wenfang;Hu Xiaona;Guo Min;Liu Li(Delivery Room,Tangshan Maternal and Child Health Hospital,Tangshan Hebei 063000,P.R.China)

机构地区：[1]唐山市妇幼保健院产房,河北唐山063000

出　　处：《中国计划生育和妇产科》2024年第2期46-50,共5页Chinese Journal of Family Planning & Gynecotokology

基　　金：河北省医学科学研究计划项目(项目编号:20231747)。

摘　　要：目的分析硝苯地平联合硫酸镁对子痫前期患者人类白细胞抗原G(HLA⁃G)、同型半胱氨酸(HCY)水平的影响。方法选取2020年1月至2022年7月唐山市妇幼保健院收治的108例子痫前期患者为研究对象,根据电脑抽签法分为对照组和试验组,各54例。对照组以硫酸镁治疗,试验组在对照组的基础上增加硝苯地平治疗。对比两组临床疗效、血清学指标、胎盘血流灌注参数、母婴结局、治疗安全性。结果试验组总有效率(92.59%,50/54)高于对照组(77.78%,42/54),差异有统计学意义(P<0.05)。治疗后,试验组HCY、血清胱抑素C(Cys C)低于对照组,HLA⁃G水平高于对照组,试验组胎盘血流灌注参数血流指数(FI)、血管化指数(VI)、血管化⁃血流指数(VFI)高于对照组,试验组母婴结局包括早产、剖宫产、产后大出血、胎儿窘迫、新生儿窒息发生率低于对照组,差异有统计学意义(P<0.05)。治疗期间试验组和对照组不良反应发生率比较(11.11%vs.7.41%),差异无统计学意义(P>0.05)。结论硝苯地平联合硫酸镁治疗子痫前期效果良好,可改善患者血清学指标HCY、Cys C、HLA⁃G水平,增加胎盘血流灌注,改善患者分娩后母婴结局,治疗安全性较好。Objective To analyze the effects of nifedipine combined with magnesium sulfate on human leukocyte antigen G(HLA⁃G)and homocysteine(HCY)levels in patients with preeclampsia.Methods 108 cases of preeclampsia patients admitted to Tangshan Maternal and Child Health Hospital from January 2020 to July 2022 were selected and divided into control group and study group with 54 cases in each group by computer lottery.The control group was treated with magnesium sulfate,and the study group was treated with nifedipine in addition to the control group.The clinical efficacy,serological indexes,placental blood perfusion parameters,maternal and infant outcomes and treatment safety were compared between the two groups.Results The total effective rate of study group was 92.59%(50/54),which was higher than that of control group(77.78%,42/54)(P<0.05),After treatment,HCY and serum cystatin C(Cys C)in study group were lower than those in control group,and HLA⁃G levels was higher than that in control group(P<0.05),the blood flow index(FI),vascularization index(VI)and vascularization blood flow index(VFI)of the study group were higher than those of the control group(P<0.05),the incidence of premature delivery,cesarean section,postpartum massive hemorrhage,fetal distress and neonatal asphyxia in study group were lower than those in control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups during treatment(11.11%vs.7.41%)(P>0.05).Conclusion Nifedipine combined with magnesium sulfate has a good effect on the treatment of preeclampsia,which can improve the serological indexes of patients,it can improve the serum indicators HCY,Cys C,and HLA⁃G levels in patients,increase placental blood flow perfusion,improve the maternal and infant outcomes of patients after delivery,and the treatment is safe.

关 键 词：子痫前期 硫酸镁 硝苯地平 同型半胱氨酸 血清胱抑素 人类白细胞抗原G 

分 类 号：R714.244[医药卫生—妇产科学]