新冠RNA疫苗研究进展  

Research Advances on COVID⁃19 RNA Vaccine

作　　者：赵小蒙 尹一凡 林敏 汪晨 郑子峥[1] 夏宁邵[1] 张军[1] ZHAO Xiaomeng;YIN Yifan;LIN Min;WANG Chen;ZHENG Zizheng;XIA Ningshao;ZHANG Jun(National Institute of Diagnostics and Vaccine Development in Infectious Diseases,State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics,School of Public Health,Xiamen University,Xiamen 361102,China)

机构地区：[1]厦门大学国家传染病诊断试剂与疫苗工程技术研究中心,厦门大学分子疫苗学和分子诊断学国家重点实验室,厦门大学公共卫生学院,厦门361102

出　　处：《病毒学报》2024年第1期151-159,共9页Chinese Journal of Virology

基　　金：福建省基金重点(项目号:2022J02005),题目:天然感染下非免疫优势表位的功能挖掘及免疫原展示设计。

摘　　要：新冠疫情使得RNA疫苗得到了迅速的发展。本文依据RNA分子形式的不同将RNA疫苗分为三种类型:非复制型传统mRNA疫苗、环状RNA疫苗和自复制型RNA疫苗,并对其技术特点及在新冠病毒领域的研究进展进行综述。The COVID‐19 pandemic has promoted rapid advancement of RNA vaccines.This paper reviews the technical characteristics and recent research progress of three types of RNA vaccines,which are classified based on the different forms of RNA molecules:non‐replicating traditional mRNA vaccines,circular RNA vaccines and self‐replicating RNA vaccines.

关 键 词：新冠病毒 mRNA疫苗 环状RNA疫苗 自复制型RNA疫苗 

分 类 号：R392[医药卫生—免疫学]