益气活血宽胸祛痰法治疗特发性肺纤维化的临床疗效观察  

Clinical Observation on the Treatment of Idiopathic Pulmonary Fibrosis by Traditional Chinese Medicine Method of"Yiqihuoxue and Kuanxiongqutan"

作　　者：陈勇[1] 张宏[1] Chen Yong;Zhang Hong(Department of Emergency/Traditional Chinese Medicine Classic Ward,Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China)

机构地区：[1]成都中医药大学附属医院急诊科·中医经典病房,成都610075

出　　处：《成都医学院学报》2024年第1期34-38,43,共6页Journal of Chengdu Medical College

基　　金：国家自然科学基金资助项目(No:8237153185);川财社(2022)79号中医药人才培养-国医大师陈绍宏传承工作室(No:2100601-中医/民族医专项);成都中医药大学附属医院院基金(No:19ZL14)。

摘　　要：目的观察益气活血宽胸祛痰法对特发性肺纤维化(IPF)的临床治疗效果。方法选取2019年9月至2020年12月就诊于成都中医药大学附属医院急诊科/中医经典病房的41例IPF患者为研究对象,按照随机数字表法分为试验组21例,对照组20例。对照组给予西医常规治疗,试验组在对照组治疗基础上采用“益气活血宽胸祛痰”中药汤剂,每日3次,每次100mL,疗程3个月。比较两组治疗前后中医证候积分、血气分析和肺功能检查结果及6分钟步行试验(6MWT)距离。结果治疗后试验组总有效率和6MWT距离均高于对照组(P<0.05);中医证候主症咳痰、咳嗽、喘息症状评分及中医证候总积分均低于对照组(P<0.05);治疗后两组肺功能中肺一氧化碳弥散量(DLCO)占预计值百分比(DLCO%)水平较治疗前升高,且试验组高于对照组(P<0.05);血气分析中试验组氧分压(PO_(2))指标高于对照组(P<0.05)。结论益气活血宽胸祛痰法可改善试验组患者中医证候量化评分、血气PO_(2)水平,增强肺弥散功能,提高6MWT距离;同时可减缓肺通气功能障碍的下降进程,改善临床症状,较西医常规治疗更具有优势。Objective To observe the clinical effect of the traditional Chinese medicine(TCM)"Yiqihuoxue and Kuanxiongqutan"decoction(with the function of"supplementing Qi,promoting blood circulation,relaxing chest and expelling phlegm")in the treatment of idiopathic pulmonary fibrosis(IPF).Method A total of 41 patients with IPF admitted to the Emergency Department(TCM Classic Ward)of the Hospital of Chengdu University of TCM from September 2019 to December 2020 were selected as the study objects.They were randomly divided into either an experimental group(n=21)or a control group(n=20).Both groups were given conventional Western medicine treatment,and the experimental group was additionally given the TCM decoction with the function of"supplementing Qi,promoting blood circulation,relaxing chest and expelling phlegm",100 mL each time,three times a day,for 3 months.The TCM syndrome score,and results of arterial blood gas analysis,pulmonary function test and 6-minute walk test(6MWT)were evaluated and compared between the two groups before and after treatment.Results Compared with the control group,the experimental group had higher total effective rate and distance of 6MWT after treatment(P<0.05).The total score of TCM syndrome and the scores of cough,expectoration and wheezing in the experimental group were lower than those in the control group(P<0.05).After treatment,the test results of pulmonary function(including pulmonary ventilation function and pulmonary diffusion function),and the level of diffusing capacity of the lung for carbon monoxide(DLCO)%increased in both groups,and those in the experimental group were higher than those in the control group(P<0.05).And the partial pressure of oxygen(PO_(2))index of arterial blood gas analysis in the experimental group was higher than that in the control group(P<0.05).Conclusion The integrated Western medicine and TCM decoction with the function of"supplementing Qi,promoting blood circulation,relaxing chest and expelling phlegm"is superior to Western medicine alone in improving the

关 键 词：特发性肺纤维化 中医药 临床研究 

分 类 号：R259[医药卫生—中西医结合]