基于机器学习的2型糖尿病与骨代谢的关联性研究  

Association study on bone metabolism in type 2 diabetes by using machine learning

作　　者：胡嘉桐 刘明晴 李红旗 岳佳音 王炜 刘际 Jiatong Hu;Mingqing Liu;Hongqi Li;Jiayin Yue;Wei Wang;Ji Liu(National Engineering Laboratory for Brain-inspired Intelligence Technology and Application,School of Information Science and Technology,University of Science and Technology of China,Hefei 230027,China;Department of Endocrinology,The First Affiliated Hospital of USTC,Division of Life Sciences and Medicine,University of Science and Technology of China,Hefei 230001,China;Institute of Artificial Intelligence,Hefei Comprehensive National Science Center,Hefei 230088,China;Department of Geriatric Medicine,The First Affiliated Hospital of USTC,Division of Life Sciences and Medicine,University of Science and Technology of China,Hefei 230001,China;CAS Key Laboratory of Brain Function and Diseases,School of Life Sciences,University of Science and Technology of China,Hefei 230027,China)

机构地区：[1]中国科学技术大学信息科学技术学院,类脑智能技术及应用国家工程实验室,安徽合肥230027 [2]中国科学技术大学生命科学与医学部,中国科学技术大学附属第一医院内分泌科,安徽合肥230001 [3]合肥综合性国家科学中心人工智能研究院,安徽合肥230088 [4]中国科学技术大学生命科学与医学部,中国科学技术大学附属第一医院老年医学科,安徽合肥230001 [5]中国科学技术大学生命科学学院,中国科学院脑功能与脑疾病重点实验室,安徽合肥230027

出　　处：《中国科学技术大学学报》2023年第12期30-38,I0005,I0010,共11页JUSTC

基　　金：supported by the National Natural Science Foundation of China(31970950,91957112).

摘　　要：2型糖尿病常伴有严重的并发症,包括骨代谢性疾病、肝病、肾病等,受病程、性别、年龄和个体差异的影响,没有统一的治疗模式。因此,深入分析临床数据、寻找2型糖尿病并发症数据的相关性,对2型糖尿病及其并发症的治疗具有重要的指导意义。本文以安徽省2型糖尿病患者的临床数据为基础,建立多元线性回归模型。我们的研究结果表明,影响2型糖尿病骨并发症的主要因素包括体型指数、肌酸酐、尿酸、甘油三酯和血压。有趣的是,2型糖尿病患者的腰椎骨密度增加,这表明2型糖尿病患者存在腰椎骨质增生的风险。Type 2 diabetes mellitus is often accompanied by serious complications,including bone metabolic diseases,liver diseases,and kidney diseases,which are affected by the course of disease,sex,age and individual differences and cannot be a unified treatment paradigm.Therefore,for the in-depth analysis of clinical data,looking for the correlation of type 2 diabetes complication data has important guiding significance for the treatment of type 2 diabetes and its complications.In this paper,multiple linear regression models were established based on the clinical data of type 2 diabetes patients in Anhui Province.Our results suggest that the main factors affecting bone complications of type 2 diabetes include body shape indexes,creatinine,uric acid,triglycerides and blood pressure.Interestingly,the bone mineral density of lumbar vertebrae in patients with type 2 diabetes was increased,suggesting that there was a risk of lumbar hyperosteogeny.

关 键 词：2型糖尿病 机器学习 多元线性回归模型 骨代谢 

分 类 号：R587.2[医药卫生—内分泌]