表面活性剂Tween 20对纳米乳液在唾液、胃液和肠液中胶体稳定性的影响  

Effects of Surfactant Tween 20 on the Colloidal Stability of Nanoemulsions in Saliva,Gastric Juice and Intestinal Fluid

作　　者：杨嘉辉 王星艳 罗诗睫 李丽华 钟文秀 张锦瑾 陈澄宇 YANG Jiahui;WANG Xingyan;LUO Shijie;ZHONG Wenxiu;ZHANG Jinjin;CHEN Chengyu(College of Natural Resources and Environment,Guangdong Provincial Key Laboratory of Agricultural&Rural Pollution Abatement and Environmental Safety,South China Agricultural University,Guangzhou 510642,China)

机构地区：[1]华南农业大学资源环境学院广东省农业农村污染治理与环境安全重点实验室,广东广州510642

出　　处：《广东轻工职业技术学院学报》2024年第1期1-8,共8页Journal of Guangdong Industry Polytechnic

基　　金：广东省创新创业团队引进计划(2019ZT08N291);广东省基础与应用基础研究基金(2023A1515030101、2021A1515011503);国家自然科学基金(42377418);广州市科技规划项目(202201010505);华南农业大学提质增效原始创新培育项目(4200-2023378)。

摘　　要：乳液体系已广泛应用于工业活动和日常生活中,胶体稳定性是一个关键参数。因此,本次实验通过将大豆油和水与表面活性剂失水山梨醇聚氧乙烯(20)醚月桂酸酯(Tween 20)混合制备研究水包油乳液的胶体稳定性。采用动态光散射技术,通过粒径和ζ电位测量,考察了沉淀时间和乳化剂浓度对纳米乳液胶体稳定性的影响。样品制备1天后,纳米乳液在Tween 20浓度为2-5%(重量)下保持稳定,最佳表面活性剂浓度是3.5%,在该浓度下ζ电位和粒径分别为-35.93 mV和37.17 nm。进一步研究了胶体在唾液、胃液和肠液等体液中的稳定性,结果显示颗粒大小差异不显著。Emulsion systems have been widely used in industrial activities and daily life,with colloidal stability being a key parameter.The colloidal stability of an oil-in-water emulsion prepared by mixing soybean oil and water with surfactant polyoxyethylene sorbitan monolaurate(Tween 20)was therefore investigated.The effects of settling time and emulsifier concentration on the colloidal stability of nanoemulsions were examined by particle size and zeta potential measurements with dynamic light scattering technique.The nanoemulsions remained stable at 2-5%(wt.)of Tween 20 concentrations after 1 day of sample preparation,yielding an optimum surfactant concentration of 3.5%at which the zeta potential and particle size were-35.93 mV and 37.17 nm,respectively.The colloidal stability was further studied in body fluids including saliva,gastric juice,and intestinal fluid,which showed insignificant difference on particle size.The results indicated that 3.5%of surfactant Tween 20 could effectively stabilize the nanoemulsions in various body fluids.

关 键 词：纳米乳液 Tween 20 表面活性剂 胶体稳定性 体液 

分 类 号：O648[理学—物理化学]