Oxygen Penetration Through Full-Thickness Skin by Oxygen-Releasing Sutures for Skin Graft Transplantation  

作　　者：Wenjing Zai Yunong Yuan Lin Kang Jialong Xu Yiqiao Hu Lifeng Kang Jinhui Wu 

机构地区：[1]State Key Laboratory of Pharmaceutical Biotechnology,Medical School,Nanjing University,Nanjing 210093,China [2]School of Pharmacy,Faculty of Medicine and Health,University of Sydney,Sydney,NSW 2006,Australia [3]School of Biomedical Engineering,Shanghai Jiao Tong University,Shanghai 200240,China [4]Chemistry and Biomedicine Innovation Center,Nanjing University,Nanjing 210023,China [5]Jiangsu Provincial Key Laboratory for Nano Technology,Nanjing University,Nanjing 210093,China [6]Jiangsu Food&Pharmaceutical Science College,Huai’an 223003,China

出　　处：《Engineering》2023年第10期83-94,共12页工程（英文）

基　　金：supported by the National Key Research and Development Program of China(2022YFC3401600);the National Natural Science Foundation of China(32171372);the Program A for Outstanding PhD Candidate of Nanjing University(202102A004);the Logistics Research Projects(BWS20J017);the University of Sydney–China Scholarship Council(USYD-CSC)scholarship(202008320366)。

摘　　要：The transplantation of full-thickness skin grafts(FTSGs)is important for reconstructing skin barrier and promoting wound healing.Sufficient oxygen supply is closely related to the success of skin grafting.However,full-thickness oxygen delivery is limited by the poor oxygen permeability of skin.Oxygen-releasing sutures(O_(2)sutures)were developed to facilitate oxygen penetration through full-thickness skin.The O_(2)sutures delivered 100 times more oxygen than topical gaseous oxygen therapy at a 15 mm depth in the skin model.Under extreme hypoxia(<0.5%O_(2),v/v),O_(2)sutures could also promote endothelial cell proliferation.After the transplantation of FTSGs in mice,O_(2)sutures accelerated blood re-perfusion and increased the survival area of the skin graft.It is expected that O_(2)sutures will be adopted in clinical applications to increase the success rate of full-thickness skin transplantation.

关 键 词：WOUND Skin graft transplantation Oxygen-releasing sutures Full-thickness oxygen delivery 

分 类 号：R622.1[医药卫生—整形外科]