NS患儿血清sTREM-1、TGF-β1表达及意义  

The expression and significance of serum sTREM-1 and TGF-β1 in children with moderate NS

作　　者：彭菲 刘春艳 Peng Fei;Liu Chunyan(Fetomaternal Health Care Facility of Shiyan City of Hubei Province,Shiyan,Hubei,442000,China)

机构地区：[1]十堰市妇幼保健院儿科,湖北十堰442000

出　　处：《现代科学仪器》2024年第1期59-64,共6页Modern Scientific Instruments

摘　　要：目的:分析肾病综合征(NS)患儿血清可溶性髓系细胞触发受体-1(sTREM-1)、转化生长因子-β1(TGF-β1)的表达水平及临床意义。方法:选取180例NS患儿,检测并对比治疗前后血清sTREM-1、TGF-β1水平,分析二者临床意义。结果:治疗后NS患儿血清sTREM-1、TGF-β1均水平降低,且缓解组低于未缓解组(P<0.05);血清sTREM-1、TGF-β1水平预测NS患儿治疗效果的AUC分别为0.845、0.883。结论:血清sTREM-1、TGF-β1水平与NS患儿病情活动状态有关,可预测NS患儿治疗效果,且两者联合预测效果更佳。Objective:To analyze the expression and clinical significance of serum soluble tigering receptor expressed on myeloid cells-1(sTREM-1)and transforming growth factor b1(TGF-β1)in children with nephrotic syndrome(NS).Method:180 children with NS were selected and their serum levels of sTREM-1 and TGF-β1 were measured and compared before and after treatment,to analyze their clinical significance.Result:After treatment,the serum levels of sTREM-1 and TGF-β1 in NS patients decreased,and the remission group was lower than the unremission group(P<0.05).The AUC of serum sTREM-1 and TGF-β1 levels predicting treatment efficacy in children with NS were 0.845 and 0.883,respectively.Conclusion:The serum levels of sTREM-1 and TGF-β1 are related to the activity status of NS patients,which can predict the treatment effect of NS patients,and the combination of the two has a better predictive effect.

关 键 词：肾病综合征 可溶性髓系细胞触发受体-1 转化生长因子-Β1 

分 类 号：R446.1[医药卫生—诊断学]