TIMP3/MMP9通路与非小细胞肺癌上皮间质转化的相关性研究  

Correlation of TIMP3/MMP9 Pathway Related Protein Expression with Epithelial-mesenchymal Transition in Non-small Cell Lung Cancer

作　　者：宣自磊 裴志强 丁瑞阳 杨文柱 Xuan Zilei;Pei Zhiqiang;Ding Ruiyang;Yang Wenzhu(Department of Respiratory Medicine,Affiliated Hospital of Wanxi Health Vocational College,Lu'an 237000,Anhui,China)

机构地区：[1]皖西卫生职业学院附属医院呼吸科,安徽六安237000

出　　处：《现代科学仪器》2024年第1期111-115,共5页Modern Scientific Instruments

基　　金：2018年度安徽省自然科学基金项目(编号:1808085MH229)。

摘　　要：目的:研究TIMP3/MMP9通路与非小细胞肺癌上皮间质转化的相关性。方法:选取2020年6月-2022年3月皖西卫生职业学院附属医院49例非小细胞肺癌患者癌组织以及22例患者癌旁组织,比较TIMP3/MMP9通路相关蛋白差异并采用spearman法检验其相关性。结果:非小细胞肺癌组织与癌旁组织间,组织分化程度、TNM分期、淋巴结转移间TIMP3/MMP9通路相关蛋白比较差异明显(P<0.05);spearman分析结果显示:TIMP3与E-钙黏蛋白呈正相关(P<0.05),与波形蛋白呈负相关(P<0.05),MMP9与E-钙黏蛋白呈负相关(P<0.05),与波形蛋白呈正相关(P<0.05)。结论:TIMP3/MMP9通路与非小细胞肺癌上皮间质转化相关。Objective:To investigate the correlation between the TIMP3/MMP9 pathway and epithelial mesenchymal transition in non-small cell lung cancer.Method:From June 2020 to March 2022,49 cancer tissues of non-small cell lung cancer patients and 22 adjacent tissues of patients were selected from the affiliated hospital of Wanxi Health Vocational College.The differences in TIMP3/MMP9 pathway related proteins were compared and their correlation was tested using Spearman method.Result:There were significant differences in TIMP3/MMP9 pathway related proteins in tissue differentiation,TNM staging,and lymph node metastasis between non-small cell lung cancer and adjacent tissues(P<0.05),Spearman analysis showed that TIMP3 was positively correlated with E-cadherin(P<0.05),negatively correlated with Vimentin(P<0.05),and MMP9 was negatively correlated with E-cadherin(P<0.05),positively correlated with Vimentin(P<0.05).Conclusion:The TIMP3/MMP9 pathway is associated with epithelial mesenchymal transition in non-small cell lung cancer.

关 键 词：组织蛋白酶抑制剂3 金属蛋白酶9 非小细胞肺癌 上皮间质转化 

分 类 号：R563[医药卫生—呼吸系统]