枸杞化学成分和药理作用研究进展及质量标志物的预测分析  

Research Progress of Gouqi(Lycium barbarum)and Predictive Analysis on lts Q-markers

作　　者：张雪燕 戴瑜婷 王艺璇 何洋 何廷伟 刘永琦[3,4] 和建政 修明慧 ZHANG Xueyan;DAI Yuting;WANG Yixuan;HE Yang;HE Tingwei;LIU Yongqi;HE Jianzheng;XIU Minghui(School of Public Health,Gansu University of Chinese Medicine,Lanzhou 730000,Gansu,China;Gansu University of Chinese Medicine,The First Clinical Clinical Medical College,Lanzhou 730000,Gansu,China;Provincial-Level Key Laboratory for Molecular Medicine of Major Diseases and Study on Prevention and Treatment of Traditional Chinese Medicine,Gansu University of Chinese Medicine,Lanzhou 730000,Gansu,China;Key Laboratory of Dunhuang Medicine and Transformation Ministry of Education,Gansu University of Chinese Medicine,Lanzhou 730000,Gansu,China;School of Basic Medicine,Gansu University of Chinese Medicine,Lanzhou 730000,Gansu,China)

机构地区：[1]甘肃中医药大学公共卫生学院,甘肃兰州730000 [2]甘肃中医药大学第一临床医学院,甘肃兰州730000 [3]甘肃中医药大学,甘肃省高校重大疾病分子医学与中医药防治研究重点实验室,甘肃兰州730000 [4]甘肃中医药大学,敦煌医学与转化教育部重点实验室,甘肃兰州730000 [5]甘肃中医药大学基础医学院,甘肃兰州730000

出　　处：《中华中医药学刊》2024年第1期174-183,I0002,共11页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金青年科学基金项目(82004228,82104562);甘肃省教育厅高等学校产业支撑计划项目(2020C-15)。

摘　　要：枸杞是一种药食两用药材,被广泛应用于保健食品的加工中。研究表明其含有多糖类、黄酮类、花色苷类、原花青素类、生物碱类等多种化学成分,且具有免疫调节、抗衰老、降糖调脂、降压、抗肿瘤等药理作用。通过对枸杞的主要化学成分和药理作用进行综述,在此基础上,结合质量标志物(Q-marker)理论的研究思路,从传统功效、植物亲缘学、化学成分有效性等方面进行枸杞质量标志物预测,为枸杞的进一步开发利用提供科学依据。Gouqi(Lycium barbarum)is a kind of plant with dual use of medicine and food,and is widely used in health food processing.Studies show that it contains polysaccharide,flavonoids,anthocyanins,procyanidins,alkaloids and other chemical components.It contains various chemical components such as polysaccharides,flavonoids,anthocyanins,proanthocyanidins and alkaloids,and has pharmacological effects such as immune regulation,anti-aging,hypoglycemic and lipid-lowering,antihypertensive and anti-tumor effects.This article reviewed the main chemical components and pharmacological effects of Gouqi(Lycium barbarum).Based on this,combined with the research ideas of quality marker(Q-marker)theory,it predicted the Q-markers of Gouqi(Lycium barbarum)from traditional efficacy,plant phylogeny,chemical component effectiveness and other aspects,providing scientific basis for the further development and utilization of Gouqi(Lycium barbarum).

关 键 词：枸杞 枸杞多糖 黄酮类 花色苷类 原花青素类 生物碱类 质量标志物 

分 类 号：R284.1[医药卫生—中药学]