丹葛汤加减结合温针灸治疗颈性眩晕症疗效及对椎-基底动脉血流速度的影响  

Effect of Dange Decoction(丹葛汤)and Warm Acupuncture on Cervical Vertigo and Its Influence on Vertebrobasilar Artery Blood Flow Velocity

作　　者：潘华 兰昊 郝坤 PAN Hua;LAN Hao;HAO Kun(The Second Affiliated Hospital of Nanyang Medical College,Nanyang 473000,Henan,China)

机构地区：[1]南阳医专第二附属医院,河南南阳473000

出　　处：《中华中医药学刊》2024年第1期205-209,共5页Chinese Archives of Traditional Chinese Medicine

基　　金：河南省医学科技攻关计划项目(2018020944)。

摘　　要：目的观察丹葛汤加减结合温针灸治疗颈性眩晕症(CV)的疗效及对椎-基底动脉血流速度的影响。方法选取2019年1月—2022年1月医院收治的138例CV患者随机分为对照组(给予温针灸治疗)和观察组(在对照组的基础上另给丹葛汤加减治疗),每组69例。连续治疗2周后评价治疗效果。对比两组患者中医临床症状评分、临床疗效、椎-基底动脉血流速度、血液流变学指标及血浆内皮素(ET-1)、降钙素基因相关肽(CGRP)水平。对比两组患者治疗期间不良反应。结果治疗前两组患者主症、次症及总分对比,差异无统计学意义(P>0.05);治疗后主症、次症及总分均降低(P<0.05),且治疗后观察组主症、次症及总分均低于对照组(P<0.05)。观察组总有效率为95.65%(66/69)高于对照组85.51%(59/69)(P<0.05)。观察组治疗1周、2周后左侧椎动脉、右侧椎动脉及基底动脉血流速度均高于对照组(P<0.05)。观察组治疗2周后的全血黏度、红细胞聚集指数均低于对照组(P<0.05)。观察组治疗1周后、治疗2周后的血浆ET-1高于对照组(P<0.05),血浆CGRP水平则高于对照组(P<0.05)。两组患者治疗期间均无明显不良反应。结论丹葛汤加减结合温针灸治疗CV可有效缓解患者临床症状,提高临床疗效,改善椎-基底动脉血流速度和血液流变学指标,平衡血浆ET-1、CGRP水平,且安全可靠。Objective To observe the curative effect of modified Dange Decoction(丹葛汤)combined with warm acupuncture in the treatment of cervical vertigo(CV)and its effect on vertebrobasilar blood flow velocity.Methods A total of 138 CV patients admitted to the hospital from January 2019 to January 2022 were randomly divided into a control group(treated with warm acupuncture and moxibustion)and an observation group(treated with modified Dange Decoction on the basis of the control group),69 cases in each group.The therapeutic effect was evaluated after 2 weeks of continuous treatment.The TCM clinical symptom scores,clinical efficacy,vertebral-basilar artery blood flow velocity,hemorheological indexes and levels of endothelin(ET-1)and calcitonin gene-related peptide(CGRP)in plasma were compared between the two groups.The adverse reactions during treatment were compared between the two groups.Results There was no significant difference in the main symptoms,secondary symptoms or total scores between the two groups before treatment(P>0.05).After treatment,the main symptoms,secondary symptoms and total scores were decreased(P<0.05),and the main symptoms,secondary symptoms and total scores in the observation group were lower than those in the control group after treatment(P<0.05).The total effective rate of the observation group was 95.65%(66/69),higher than that of the control group(85.51%,59/69)(P<0.05).The blood flow velocities of the left vertebral artery,right vertebral artery and basilar artery in the observation group were higher than those in the control group after 1 and 2 weeks of treatment(P<0.05).The whole blood viscosity and erythrocyte aggregation index in the observation group after 2 weeks of treatment were lower than those in the control group(P<0.05).The plasma ET-1 levels of the observation group after 1 and 2 weeks of treatment were higher than those of the low control group(P<0.05),and the plasma CGRP level was higher than that of the low control group(P<0.05).There were no obvious adverse reactions in the

关 键 词：丹葛汤 温针灸 颈性眩晕症 临床疗效 椎-基底动脉 血流速度 

分 类 号：R255.3[医药卫生—中医内科学] R245.31[医药卫生—中医学]