药物洗脱支架体内体外相关性研究  

In Vivo and in Vitro Correlation Study of Drug-Eluting Stents

作　　者：李沅[1] 梁慧媛 董双鹏[1] 王翔宇 LI Yuan;LIANG Hui-yuan;DONG Shuang-peng;WANG Xiang-yu(Supervision and Testing Center for Medical Devices of TianJin,TianJin 300384)

机构地区：[1]天津市医疗器械质量监督检验中心,天津300384

出　　处：《中国医疗器械信息》2024年第3期25-28,共4页China Medical Device Information

摘　　要：采用A级建模方法,进行体内体外相关性分析,获得具有显著性意义的直线回归方程,体内(d)=3.42×体外(h)-0.367,通过体内体外相关性的建立,可以预测药物在体内的吸收情况。With the A modeling method for the in vivo correlation research,the in vitro release curve corresponding to each point in vivo has a linear regression,the in vivo time(days)=3.42×in vitro time(h)-0.367,in vitro correlation can predict the absorption of drug in the body.

关 键 词：药物洗脱支架 体内体外相关性 

分 类 号：TH788[机械工程—仪器科学与技术]