中医药干预Wnt/β-catenin信号通路治疗激素性骨质疏松症的研究进展  

Research Progress of the Treatment of Glucocorticoid-induced Osteoporosis with Traditional Chinese Medicine Intervention on Wnt/β-catenin Signaling Pathway

作　　者：史凡凡 赵继荣[1] 雒永生[2] 马同 陈文[2] 蔡毅 张天龙 杨涛[1] 张立存 李玮农 杨文通 蒋鹏 SHI Fanfan;ZHAO Jirong;LUO Yongsheng;MA Tong;CHEN Wen;CAI Yi;ZHANG Tianlong;YANG Tao;ZHANG Licun;LI Weinong;YANG Wentong;JIANG Peng(Gansu University of Chinese Medicine,Lanzhou 730030,China;Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730050,China)

机构地区：[1]甘肃中医药大学,甘肃兰州730030 [2]甘肃省中医院,甘肃兰州730050

出　　处：《西部中医药》2024年第3期73-76,共4页Western Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金(81760877);甘肃省自然科学基金(17JR5RA051);甘肃省中医药管理局科研课题(GZK-2018-35,GZK-2019-2);兰州市创新人才项目(2018-RC-99);兰州市科技局科研课题(2019-ZD-116);甘肃中医药大学研究生创新基金项目(CS2018-10)。

摘　　要：对Wnt/β-catenin信号通路与激素性骨质疏松症(glucocorticoid-induced osteoporosis,GIOP)相关性及中药单体、中药复方干预Wnt/β-catenin信号通路治疗GIOP的研究进行综述,指出当Wnt/β-catenin信号通路受到抑制时,骨形成减少的同时骨吸收增加,从而诱发GIOP;中药单体及复方通过调控Wnt/β-catenin信号通路抑制剂Dickkopf相关蛋白1(dickkopf related protein 1,DKK1)、组织蛋白酶K(cathepsin K,CTSK)、Wnt抑制因子1(Wnt inhibitory factor 1,WIF1)、糖原合成酶激酶3β(glycogen synthetase kinase-3β,GSK3β)、骨硬化蛋白(sclerostin protein,SOST)等表达水平,再次激活Wnt/β-catenin信号通路,从而达到防治GIOP的目的。因此,探讨中医药对Wnt/β-catenin信号通路的作用,可为防治GIOP提供有力依据,为中医药治疗GIOP提供新方向。By reviewing the connections between Wnt/β-catenin signaling pathway and glucocorticoid induced osteoporosis(GIOP),and the researches on the treatment of GIOP with herbal monomers and herbal compounds intervention on Wnt/β-catenin signaling pathway,it is found that the inhibition of Wnt/β-catenin signaling pathway is related to the occurrence and development of GIOP;herbal monomers and herbal compounds could activate Wnt/β-catenin signaling pathway again by regulating the expressions of the inhibitors of Wnt/β-catenin signaling pathway including DKK1,CTSK,WIFI,GSK3β,SOST,thereby preventing and treating GIOP.Therefore,the exploration into the effects of TCM on Wnt/β-catenin signaling pathway could provide the powerful reference for the prevention and the treatment of GIOP and the new direction for TCM therapy of GIOP.

关 键 词：骨质疏松症 激素性 WNT/Β-CATENIN信号通路 中医药 

分 类 号：R274.9[医药卫生—中西医结合]