加减参芪地黄汤治疗慢性肾脏病3-4期的临床研究  

Clinical Effect of Modified Shenqi Dihuang Decoction on Chronic Kidney Disease Stages 3–4

作　　者：任燕[1] 段星星[1] 董宏利 李一林 蒋春波[1] 周丽霞 周岚[1] REN Yan;DUAN Xingxing;DONG Hongli;LI Yilin;JIANG Chunbo;ZHOU Lixia;ZHOU Lan(Suzhou Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine,Suzhou 215000,China)

机构地区：[1]南京中医药大学附属苏州市中医医院,江苏苏州215000

出　　处：《基层中医药》2024年第1期16-21,共6页Basic Traditional Chinese Medicine

基　　金：苏州市科技发展计划项目(SKYXD2022060、KJXW2022040、SYSD2019156);2020年苏州市卫生青年骨干人才“全国导师制”培训项目;江苏省老年医学学会2019年度老年医学科技发展基金(医养结合)专项项目(JGS2019ZXYY019)。

摘　　要：目的探讨加减参芪地黄汤在慢性肾病3-4期患者临床治疗中的作用。方法将2019年1月至2023年5月在苏州市中医医院住院及门诊治疗的慢性肾病3-4期患者60例,按随机数字表分组,各30例。对照组在常规治疗的基础上辅以肾衰宁片口服,治疗组在常规治疗的基础上给予加减参芪地黄汤中药治疗。检测两组患者肌酐、尿素氮、尿酸等指标,比较两组患者中医证候积分及临床疗效。结果治疗组总有效率为86.67%,显著高于对照组(77.33%)(P<0.05)。治疗组治疗后血Scr、BUN、UA显著低于对照组,差异具有统计学意义(P<0.05)。治疗组倦怠乏力、食少纳呆、腰膝酸软、肢体困重等证候积分与对照组比较均有统计学差异(P<0.01或P<0.05)。结论加减参芪地黄汤对慢性肾病3-4期患者疗效良好,可降低血肌酐、尿素氮、尿酸,改善临床症状,延缓慢性肾脏病进展。Objective To investigate the clinical effect of Shenqi Dihuang Decoction on the patients with chronic kidney disease stages 3–4.Methods A total of 60 patients with chronic kidney disease stages 3–4 who were treated in Suzhou Hospital of Traditional Chinese Medicine from January 2019 to May 2023 were assigned by the random number table method into a control group and an observation group,each with 30 patients.On the basis of conventional treatment,the patients in the control group were treated with Shenshuaining tablets,and those in the observation group with modified Shenqi Dihuang Decoction.The levels of serum creatinine(Scr),blood urea nitrogen(BUN),and uric acid(UA)in the two groups were measured.The traditional Chinese medicine(TCM)symptom scores and clinical efficacy were compared between the two groups.Results The total response rate in the observation group was 86.67%,which was higher than that(77.33%)in the control group(P<0.05).After treatment,the observation group had lower levels of Scr,BUN,and UA than the control group(P<0.05).There were differences in the scores of fatigue,poor appetite,waist and knee pain,and limb weakness between the two groups(P<0.01 or P<0.05).Conclusion Shenqi Dihuang Decoction demonstrates definite effects on patients with chronic kidney disease stages 34.It can reduce Scr,BUN,and UA,alleviate clinical symptoms,and delay the progression of chronic kidney disease.

关 键 词：参芪地黄汤 慢性肾脏病3-4期 临床疗效 

分 类 号：R27[医药卫生—中医学]