包被纳米氧化锌对断奶仔猪生长性能、免疫功能和肠道屏障的影响  

Effects of coated nano zinc oxide on growth performance,immune function,and intestinal barrier of weaned piglets

作　　者：李慧 刘金松 刘玉兰 张严 孔随飞 曹广添[2] LI Hui;LIU Jin-song;LIU Yu-lan;ZHANG Yan;KONG Sui-fei;CAO Guang-tian

机构地区：[1]浙江惠嘉生物科技股份有限公司,浙江湖州313300 [2]中国计量大学,浙江杭州310018

出　　处：《饲料研究》2024年第2期16-20,共5页Feed Research

基　　金：浙江省领军型创业创新团队项目(项目编号:2020R01015)。

摘　　要：研究旨在比较不同形式纳米氧化锌对断奶仔猪生长性能、免疫功能和肠道屏障的影响。选取192头24日龄左右、体重(7.47±0.62)kg的断奶仔猪(公、母各半),随机分为4组,每组6个重复,每个重复8头仔猪。对照组饲喂基础饲粮,试验Ⅰ组、试验Ⅱ组、试验Ⅲ组分别在基础饲粮中添加2000 mg/kg纳米氧化锌、500 mg/kg包被纳米氧化锌、1000 mg/kg包被纳米氧化锌。试验期14 d。结果显示,纳米氧化锌的总有效率为7.12%,远低于包被纳米氧化锌的78.54%;不同形式纳米氧化锌均可以显著提高断奶仔猪的试验末重和平均日增重(P<0.05),显著降低料重比和腹泻率(P<0.05),试验Ⅲ组效果最佳;与对照组相比,各试验组断奶仔猪血清中免疫球蛋白M和免疫球蛋白A含量显著提高(P<0.05),试验Ⅰ组和试验Ⅲ组断奶仔猪空肠和回肠的分泌型免疫球蛋白水平显著提高(P<0.05);不同形式纳米氧化锌均显著降低了断奶仔猪血清中二胺氧化酶活性和内毒素含量(P<0.05)。研究表明,在饲粮中添加纳米氧化锌和包被纳米氧化锌均可促进断奶仔猪生长,降低腹泻率,增强免疫功能和肠道屏障功能,1000 mg/kg包被纳米氧化锌的作用效果较好。The study was conducted to compare the effects of different forms of nano-zinc oxide on the growth performance,immune function,and intestinal barrier of weaned piglets.A total of 192 weaned piglets aged 24 days(half in male and female),with an average weight of(7.47±0.62)kg were randomly divided into four groups,with six replicates in each group and eight piglets in each replicate.The control group was fed a basal diet,and the experimental groupⅠ,groupⅡand groupⅢwere fed with 2000 mg/kg nano-zinc oxide,500 mg/kg coated nano-zinc oxide,1000 mg/kg coated nano-zinc oxide,respectively.The experiment lasted for 14 days.The results showed that the total effective rate of nano zinc oxide was 7.12%,which was lower than that of coated nano zinc oxide(78.54%).All forms of nano zinc oxide significantly increased the final weight and average daily gain of weaned piglets(P<0.05),and significantly decreased the ratio of feed to gain and diarrhea rate(P<0.05),with the best effects observed in the experiment groupⅢ.Compared with the control group,the levels of immunoglobulin M and immunoglobulin A in the serum of weaned piglets in all experimental groups were significantly increased(P<0.05),and the secretion of immunoglobulin in the cecum and colon was significantly elevated in the experiment groupⅠand experiment groupⅢ(P<0.05).Different forms of nano zinc oxide significantly decreased the serum diamine oxidase activity and endotoxin content in weaned piglets(P<0.05).The study indicates that dietary supplementation of nano zinc oxide and coated nano zinc oxide of weaned piglets can promote growth,reduce diarrhea rate,enhance immune function,and improve intestinal barrier function.The effects of 1000 mg/kg of coated nano zinc oxide are better.

关 键 词：包被纳米氧化锌 断奶仔猪 生长性能 免疫功能 肠道屏障 

分 类 号：S828[农业科学—畜牧学]