维生素K3的催化合成研究  

Study on Catalytic Synthesis of Vitamin K3

作　　者：孙同乐 董明燕 任倩 吕绪涛 张立鹏 岳涛 Sun Tongle;Dong Mingyan;Ren Qian;Lyu Xutao;Zhang Lipeng;Yue Tao(Shandong Genyuan New Materials Co.,Ltd.,Weihai 264499,China;Qingdao University of Chemical Technology Academy of Shandong Province,Science and Technology,Organic Reaction in Aqueous Engineering Research Center of Shandong Province,Jinan 250014,China)

机构地区：[1]山东亘元新材料股份有限公司,山东威海264499 [2]青岛科技大学山东化工研究院山东省水相有机合成及高效清洁分离工程技术研究中心,山东济南250014

出　　处：《山东化工》2024年第2期45-47,共3页Shandong Chemical Industry

摘　　要：2-甲萘醌合成存在成本高、废水处理量大、选择性低、产品分离困难等问题,根据2-甲萘醌性质,以浓硫酸(98%)为催化剂、2-甲基萘与过氧化氢为反应原料、乙酸为溶剂,确定2-甲萘醌合成最佳条件为:以浓硫酸为催化剂、催化剂用量为1.5%、氧化剂为过氧化氢、n(过氧化氢):n(二甲萘)=1.8、反应时间5 h、反应温度60℃。浓硫酸做催化剂先将溶剂乙酸催化氧化成过氧乙酸,过氧乙酸将甲基萘初步氧化,然后通过双氧水缓慢氧化成2-甲萘醌。通过该工艺实现2-甲基萘的转化率46.37%、2-甲萘醌收率39.45%、选择性90.34%。The synthesis of 2-menadione faces challenges such as high cost,a large wastewater treatment capacity,low selectivity,and difficulty in product separation.Considering the properties of 2-menadione,concentrated sulfuric acid(98%)was chosen as the catalyst,2-methylnaphthalene as the reaction raw material,and hydrogen peroxide as the oxidizer,with acetic acid as the solvent.The optimal conditions for synthesizing 2-menadione were determined as follows:concentrated sulfuric acid was used as the catalyst with a dosage of 1.5%,hydrogen peroxide was used as the oxidizer at a molar ratio of hydrogen peroxide to 2-methylnaphthalene of 1.8,the reaction time was set at 5 hours,and the reaction temperature was maintained at 60℃.Concentrated sulfuric acid functioned as the catalyst to facilitate the conversion of acetic acid into peracetic acid.This intermediate compound initially oxidized methyl naphthalene,subsequently transforming into 2-menadione through a gradual oxidation process using hydrogen peroxide.The conversion rate of 2-methylnaphthalene reached 46.37%,yielding a 39.45%output of 2-menadione with a selectivity of 90.34%.

关 键 词：2-甲基萘 2-甲萘醌 浓硫酸(98%) 过氧化氢 乙酸 

分 类 号：TQ203.9[化学工程—有机化工]