浅谈基于混合光学探针的神经膜电位成像技术  

Discussion on Neural Membrane Potential Imaging Technology Based on Hybrid Optical Probes

作　　者：王雅 马贝贝 Wang Ya;Ma Beibei(Key Laboratory of Micro and Nano Electric Sensing Technology and Biomimetic Devices,Ili Normal University,Yining 835000,China;School of Electronics and Engineering,Ili Normal University,Yining 835000,China)

机构地区：[1]伊犁师范大学微纳电传感技术与仿生器械重点实验室,伊宁835000 [2]伊犁师范大学电子与工程学院,伊宁835000

出　　处：《山东化工》2024年第2期102-104,108,共4页Shandong Chemical Industry

基　　金：2023年度伊犁师范大学校级科研项目(2023YSYB005);2022年度伊犁师范大学高级别培育项目(YSPY2022008);2021年度伊犁师范大学科研创新团队培育计划(CXZK2021011)。

摘　　要：神经膜电位是影响细胞寿命的一种电现象,即细胞膜两侧的电位差,可以监测膜电位和神经活动。结合混合光学探针技术对神经膜电位成像具有高保真和长期监测优势,广泛应用于生物物理学、细胞学和生物化学领域。该综述主要概括了混合光学探针在体内外神经活动成像中的应用,阐述了混合光学探针的设计策略和电压传感机制,展望了混合光学探针的设计和应用未来所面临的挑战和前景。Nerve membrane potential is an electrical phenomenon that affects cellular lifespan the potential difference between the two sides of the cell membrane,allowing monitoring of membrane potential and neural activity.The combination of mixed optical probe technology and neural membrane potential imaging has the advantages of high fidelity and long-term monitoring,and is widely used in the fields of biophysics,cell biology,and biochemistry.This article summarizes the application of mixed optical probes in imaging neural activity both in vitro and in vivo,explains the design strategy and voltage sensing mechanism of mixed optical probes,and prospects the challenges and prospects of mixed optical probe design and application in the future.

关 键 词：膜电位 上转换 混合纳米探针 量子点 

分 类 号：O785.5[理学—晶体学]