重构本草——威灵仙  

Reconstruction of Chinese materia medica-Chinese clematis root

作　　者：郝瑞 赵旌屹 鲍婷婷 沈梦菲 李敏[1] HAO Rui;ZHAO Jingyi;BAO Tingting;SHEN Mengfei;LI Min(Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China;Beijing University of Chinese Medicine,Beijing 100029,China)

机构地区：[1]中国中医科学院广安门医院,北京100053 [2]北京中医药大学,北京100029

出　　处：《长春中医药大学学报》2024年第3期259-261,共3页Journal of Changchun University of Chinese Medicine

基　　金：国家中医药管理局中医药创新团队及人才支持计划项目(ZYYCXTD-D-202001);中央高水平中医医院临床科研业务费资助(HLCMHPP2023006)。

摘　　要：通过古籍文献调研、中医药现代研究成果的梳理,结合中医临床及中药学等学科领域内知名专家学者的认识及应用经验,归纳出威灵仙:功效主要为祛风湿,通经络,止痛,消骨鲠。症靶为骨关节疼痛、咽喉异物感。标靶为高血尿酸、消化道息肉。现代药理研究发现威灵仙及其有效成分具有抗炎、保护软骨、解痉、降低尿酸等作用。大剂量使用威灵仙(>50 g)可能导致变态反应、消化道刺激症状,使用时应从小剂量开始,密切观察患者反应以保证用药安全。临床使用剂量为10~45 g,内服时当根据不同疾病,或同一疾病的不同阶段进行辨证使用,并积极探索威灵仙用量与症靶、标靶的量效关系。Through the investigation of ancient books and the sorting of the modern research achievements of traditional Chinese medicine,combined with the understanding and application experience of famous experts and scholars in thefields of traditional Chinese medicine clinical medicine and science of Chinese materia medica,it is concluded that Chinese clematis root mainly has the effects of dispelling wind and eliminating dampness,dredging meridians and collaterals,relieving pain,and eliminating bone sticking.The symptom targets are joint pain,and sensation of foreign body in the throat.The biochemical indicator targets are hyperuricemia and gastrointestinal polyps.Modern pharmacology studies have found that Chinese clematis root and its active ingredients have the effects of anti-inflammatory,protecting cartilage,spasmolysis,and reducing uric acid.The use of high-dose Chinese clematis root(over 50g)may lead to allergic reactions and digestive tract symptoms.Therefore,when using this drug in clinical practice,doctors should start with small doses,and closely observe patient reactions to ensure medication safety.The clinical dodage is 10-45g.When taken orally,it should be used dialectically according to different diseases or different stages of the same disease,and the dose-effect relationship between the dosage of Chinese clematis root and the symptom target and biochemical indicator target should be explored actively.

关 键 词：威灵仙 症靶 标靶 重构本草 临床回归 

分 类 号：R281[医药卫生—中药学]