质子转移聚合制备高性能β内酰胺交联共聚物  

Preparation of High-Performanceβ-Lactam Crosslinked Copolymers by Hydrogen Transfer Polymerization

作　　者：冯楷峰 宋肄业 江力 黄文艳 蒋其民 薛小强 蒋必彪 杨宏军 Kaifeng Feng;Yiye Song;Li Jiang;Wenyan Huang;Qimin Jiang;Xiaoqiang Xue;Bibiao Jiang;Hongjun Yang(Jiangsu Key Laboratory of Environmentally Friendly Polymeric Materials,School of Materials Science and Engineering,Jiangsu Collaborative Innovation Center of Photovoltaic Science and Engineering,Changzhou University,Changzhou 213164,China;Huaide College,Changzhou University,Jingjiang 214500,China)

机构地区：[1]江苏省环境友好高分子材料重点实验室常州大学材料科学与工程学院江苏省光伏科学与工程协同创新中心,江苏常州213164 [2]常州大学怀德学院,江苏靖江214500

出　　处：《高分子材料科学与工程》2023年第11期26-33,共8页Polymer Materials Science & Engineering

基　　金：江苏高校优势学科建设工程资助项目(PAPD)。

摘　　要：聚β内酰胺主链类似于多肽骨架结构,具有良好的生物相容性,在细胞黏附和细胞选择性生物材料领域具有应用前景。丙烯酰胺(AM)的质子转移聚合是制备聚β内酰胺的简易方法,但是其产物相对分子质量不高、不具力学性能。为此,文中推出先通过AM与1,4-丁二醇二丙烯酸酯(BDDA)的质子转移共聚合制备含双键的β内酰胺预聚物,然后再对其光固化交联来制备具有良好生物相容性和力学性能的可降解β内酰胺交联共聚物。通过核磁共振氢谱和傅里叶变换红外光谱仪对聚合物结构进行表征,通过拉伸性能测试对聚合物力学性能进行研究,通过四甲基偶氮唑盐比色法(MTT法)对细胞在材料上的存活率进行测试。结果表明,聚合物的拉伸强度高达56.6 MPa,断裂伸长率高达56.6%,明显高于高密度聚乙烯、聚丙烯等常用聚合物材料。不仅如此,所制备β内酰胺交联共聚物可极大地促进细胞增长,细胞存活率高达170%。Poly(β-lactam)with polypeptide-like skeleton structure has a good biocompatibility.It has been widely applied as cell adhesion and cell selective biomaterials.Generally,poly(β-lactam)can be synthesized by hydrogen transfer polymerization(HTP)of acrylamide(AM).However,the low molecular weight of the resulted polymer make it show poor mechanical properties.Herein,poly(b-lactam)prepolymers with large amounts of double bonds were firstly prepared by the hydrogen transfer copolymerization of AM and 1,4-butanediol diacrylate(BDDA).Then,the products were further crosslinked by UV,resulting crosslinked b-lactam copolymers.The structures of the resulted polymers before and after crosslinking were confirmed by nuclear magnetic resonance(1H-NMR)and Fourier infrared spectrometer(FT-IR).The mechanical properties and compatibility of the products were also studied by tensile test and methyl thiazolyl tetrazolium(MTT),respectively.The results show that the tensile strength of the polymer is up to 56.6 MPa accompanying with an elongation at break of 56.6%,which is significantly higher than those of commonly used polymers such as high-density polyethylene(HDPE)and polypropylene(PP).Moreover,the cell survival rate for these materials could get up to 170%,showing a good growth-promotion of cell for these materials.

关 键 词：聚β内酰胺 质子转移聚合 可降解聚合物 生物相容性 

分 类 号：R318.08[医药卫生—生物医学工程]