N-(苯乙基)肉桂酰胺类化合物的合成及其抗氧化活性研究  

Synthesis and Antioxidant Activity of N-(phenythyl)Cinnamonamide Compounds

作　　者：张海全[1] 黄勤英[1] 黄秀秀 陈嘉华 骆小凤 农克良[1] Zhang Haiquan;Huang Qinying;Huang Xiuxiu;Chen Jiahua;Luo Xiaofeng;Nong Keliang(College of Chemical and Biological Engineering,Guangxi Minzu Normal University,Chongzuo 532200,China)

机构地区：[1]广西民族师范学院化学与生物工程学院,广西崇左532200

出　　处：《山东化工》2024年第3期9-12,共4页Shandong Chemical Industry

基　　金：广西高校中青年教师科研基础能力提升项目(2020KY20018)。

摘　　要：植物N-(苯乙基)肉桂酰胺类化合物是一类重要的酰胺类活性成分,为寻求更高药理活性的肉桂酰胺类先导化合物,以苯甲醛、丙二酸为原料,设计合成了9种N-(苯乙基)肉桂酰胺类化合物,结构经过^(1)H NMR、^(13)C NMR、IR和MS鉴定。以抗坏血酸为对照,测定9种化合物清除·OH、DPPH·及ABTS+·的效果。抗氧化实验结果表明,部分化合物对·OH的清除效果优于抗坏血酸;9种化合物具有一定清除DPPH·及ABTS+·的能力,但效果不如抗坏血酸。该类化合物可进一步结构优化,探究其抗阿尔茨海默病、抗肿瘤等活性研究,也可作为抗氧化剂应用于食品、药品领域。Plant N-(phenythyl)cinnamonamide compounds are important amide active ingredient.In order to seek higher pharmacologically active cinnamonamide leading compounds,nine N-(phenylene ethyl)cinnamonamide compounds were designed and synthesized from benzoaldehyde and malondiacic acid.The structures of titled compounds were characterized by ^(1)H NMR,^(13)C NMR,IR and MS.Using ascorbic acid as the control,the scavenging effects of nine compounds on·OH,DPPH·and ABTS+·were studied.The results of antioxidant experiments show that some compounds have a better scavenging effect on·OH than ascorbic acid;nine compounds have a certain ability to scave DPPH·and ABTS+·,but the effect is not better than ascorbic acid.In order to study activities of anti-Alzheimer's disease and anti-tumor,they can be further structural optimization.They also can be used as antioxidants in the food and pharmaceutical fields.

关 键 词：肉桂酰胺 肉桂酸 抗氧化 自由基 合成 

分 类 号：TQ463[化学工程—制药化工]