膀胱出口梗阻诱导膀胱纤维化分子机制及治疗策略研究进展  

Research Progress on Molecular Mechanisms and Treatment Strategies of Bladder Outlet Obstruction Induced Bladder Fibrosis

作　　者：汪松 陈林 何江枢[1,2] 李嘉 龙军 杨进[2] 梁国标 吴金邦[3] 吴波 WANG Song;CHEN Lin;HE Jiangshu;LI Jia;LONG Jun;YANG Jin;LANG Guobiao;WU Jinbang;WU Bo(Zunyi Medical University,Zunyi,Guizhou 563000,China;Department of Urology,Affiliated Hospital of Chengdu University,Chengdu 610081,China;Department of Urology,the Fifth Hospital of Deyang,Deyang,Sichuan 618000,China;Department of Urology,the Third Affiliated Hospital of Chengdu Medical College,Pidu District People's Hospital,Chengdu 610036,China)

机构地区：[1]遵义医科大学,贵州遵义563000 [2]成都大学附属医院泌尿外科,成都610081 [3]德阳第五医院泌尿外科,四川德阳618000 [4]成都市郫都区人民医院泌尿外科,成都610036

出　　处：《转化医学杂志》2023年第6期386-395,共10页Translational Medicine Journal

基　　金：国家自然科学基金(81500577);四川省科技厅自然科学基金项目(2022NSFSC1592);四川省医学科研课题(S19017、S17002、Q20013、Q19022);成都大学临床医学院附属医院创新团队项目(CDFYCX202207);成都市科技局重点研发支撑计划(2022YF0501441SN)。

摘　　要：膀胱出口梗阻(BOO)诱导的膀胱纤维化可导致膀胱不可逆转的功能和结构变化,是膀胱重塑的终末期改变,严重影响患者生活质量。机械应力、缺血缺氧和炎性浸润是长期梗阻下启动膀胱纤维化的重要因素,一方面促进细胞外基质和胶原的产生,一方面抑制其降解,大量沉积于膀胱壁,使得膀胱壁顺应性降低,容量减少,收缩力下降。目前预防膀胱纤维化和改善膀胱功能的药物研究已取得重大进展,包括临床药物、天然中药成分、高分子材料及干细胞治疗等。本综述主要总结了BOO诱导膀胱纤维化的分子机制和治疗策略,为后续研究提供一定的思路和方向,也为相关药物的研发和使用提供了理论基础。Bladder outlet obstruction(BOO)-induced bladder fibrosis can lead to irreversible functional and structural changes in the bladder,which is the end-stage change of bladder remodeling and seriously affects the quality of life of patients.Mechanical stress,ischemia hypoxia,and inflammatory infiltration are important factors that initiate bladder fibrosis under long-term obstruction.On the one hand,they promote the production of extracellular matrix and collagen,while on the other hand,they inhibit their degradation and deposit a large amount on the bladder wall,resulting in a decrease in bladder wall compliance,capacity,and contraction force.At present,significant progress has been made in drug research to prevent bladder fibrosis and improve bladder function,including clinical drugs,natural Chinese herbal ingredients,polymer materials,and stem cell therapy.This review mainly summarizes the molecular mechanisms and therapeutic strategies of BOO-induced bladder fibrosis,providing certain ideas and directions for subsequent research,and also providing a theoretical basis for the development and use of related drugs.

关 键 词：膀胱出口梗阻 膀胱疾病 纤维化 分子机制 治疗 细胞外基质 胶原 综述 

分 类 号：R694[医药卫生—泌尿科学]