影响猪流感病毒致病性和传播性的关键氨基酸位点的研究进展  

Key Amino Acid Sites Affecting the Pathogenicity and Transmission of Swine Influenza Virus

作　　者：赵玉仲 王彦哲 考国鑫 桑浩田 韩乐斌 刘思当[1,2] 肖一红 ZHAO Yuzhong;WANG Yanzhe;KAO Guoxin;SANG Haotian;HAN Lebin;LIU Sidang;XIAO Yihong(College of Animal Science and Veterinary Medicine,Shandong Agricultural University,Tai’an 271018,China;Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention,Shandong Agricultural University,Tai’an 271018,China)

机构地区：[1]山东农业大学动物科技学院,泰安271018 [2]山东省动物生物工程与疾病防治重点实验室,泰安271018

出　　处：《中国动物传染病学报》2023年第6期194-201,共8页Chinese Journal of Animal Infectious Diseases

基　　金：十三五重点研发计划课题(2016YFD0500201)。

摘　　要：猪流感病毒(SIV)在猪群中广泛传播,给养猪业造成重大的经济影响。流感病毒主要是通过病毒基因组的突变和不同来源流感病毒基因组的重新组合来完成自身的进化。通过以上两种方式产生的流感病毒对动物的致病性和传播性会出现显著改变。在这篇综述中,我们对影响SIV致病性和传播性的关键氨基酸位点的突变进行了归纳和分析,为进一步研究SIV的致病机制等方面奠定了基础。Swine influenza virus(SIV)is widely spread in the swine population and has a significant economic impact on the pig industry.Mutations in the viral genome and recombination of influenza virus genomes from different strains often occur during evolution.The pathogenicity and transmissibility of influenza viruses produced by the above two methods will be significantly changed.In this review,we summarized and analyzed the mutations of key amino acid sites that affected the pathogenicity and transmissibility of SIV,and laying the foundation for further research on the pathogenic mechanism and other aspects of SIV.

关 键 词：猪流感病毒 致病性 传播性 关键氨基酸位点 

分 类 号：S852.65[农业科学—基础兽医学]