机械应力下骨细胞行为变化的研究进展  

Research progress on the behavior change of osteocytes under mechanical stress

作　　者：詹红伟 王倩[2] 移植 张蕾 张娟[2] 李燕香 耿彬[1] 吴萌[1] 夏亚一[1] 姜金[1] ZHAN Hongwei;WANG Qian;YI Zhi;ZHANG Lei;ZHANG Juan;LI Yanxiang;GENG Bin;WU Meng;XIA Yayi;JIANG Jin(Lanzhou University Second Hospital,Lanzhou 730030,China;The Second Clinical Medical College of Lanzhou University,Lanzhou 730030,China)

机构地区：[1]兰州大学第二医院,甘肃兰州730030 [2]兰州大学第二临床医学院,甘肃兰州730030

出　　处：《中国骨质疏松杂志》2024年第2期250-256,共7页Chinese Journal of Osteoporosis

基　　金：国家自然科学基金(82060405,81960403,82160422);兰州大学第二医院“萃英科技创新”计划(CY2021-MS-A07,CY2021-MS-B02);兰州大学第二医院“萃英学子科研培育”计划(CYXZ2022-32)。

摘　　要：机械应力刺激在维持骨骼正常形态、功能和自稳平衡方面起着重要作用。过去的研究普遍认为骨细胞是不活跃的细胞。近年来,对骨细胞的深入研究表明,骨细胞是骨骼中主要的机械应力感受细胞,在机械应力下的骨形成和骨重塑过程中起着关键作用。机械应力不仅可以减少骨细胞凋亡,还能促进其分化水平。此外,受机械应力刺激的骨细胞通过直接或间接的方式来调节成骨细胞和破骨细胞的分化水平,从而维持骨结构的强度和调节骨稳态。笔者拟对机械应力下骨细胞行为变化以及其与成骨细胞和破骨细胞偶联的分子机制进行综述,旨在为今后骨质疏松基础研究提供理论参考。Mechanical stimulation plays a critical role in maintaining normal bone morphology,function,and homeostasis.Previous studies have generally considered bone cells to be inactive.However,recent in-depth investigations have revealed that bone cells are the primary mechanosensitive cells within the skeletal system,playing a pivotal role in bone formation and remodeling processes under mechanical stress.Mechanical stimuli not only reduce bone cell apoptosis but also promote their differentiation.Furthermore,mechanically stimulated bone cells regulate the differentiation of osteoblasts and osteoclasts,directly or indirectly,to maintain bone structural integrity and modulate bone homeostasis.This review aims to comprehensively summarize the changes in bone cell behavior under mechanical stress and the molecular mechanisms underlying the crosstalk between osteoblasts and osteoclasts.It aims to provide a theoretical reference for future research on osteoporosis.

关 键 词：机械应力 骨细胞 骨稳态 成骨细胞 破骨细胞 

分 类 号：R336[医药卫生—人体生理学]