细胞外ATP激活受体P2X7在骨质疏松症中的作用机制  

Mechanistic in the role of the extracellular ATP-activated receptor P2X7 in osteoporosis

作　　者：张浩龙 赵瑞 潘静 齐雅茜 雷新宇 白金霞 张忠文 王薇 张浩令 宋志靖 ZHANG Haolong;ZHAO Rui;PAN Jing;QI Yaqian;LEI Xinyu;BAI Jinxia;ZHANG Zhongwen;WANG Wei;ZHANG Haoling;SONG Zhijing(Advanced Institute for Medical and Dental Research,Universiti Sains Malaysia,Penang 13200,Malaysia;College of Traditional Chinese Medicine,Gansu University of Chinese Medicine,Lanzhou 730000,China;College of Acupuncture and Tuina,Gansu University of Chinese Medicine,Lanzhou 730000,China;School of Public Health,Gansu University of Chinese Medicine,Lanzhou 730000,China;Key Laboratory of Dunhuang Medicine and Translational Education,Ministry of Education,Lanzhou 730000,China)

机构地区：[1]马来西亚理科大学高级医学和牙科研究所,马来西亚槟城13200 [2]甘肃中医药大学中医临床学院,甘肃兰州730000 [3]甘肃中医药大学针灸推拿学院,甘肃兰州730000 [4]甘肃中医药大学公共卫生学院,甘肃兰州730000 [5]敦煌医学与转化教育部重点实验室,甘肃兰州730000

出　　处：《中国骨质疏松杂志》2024年第2期299-304,共6页Chinese Journal of Osteoporosis

基　　金：国家自然科学基金(81960877);甘肃省高等学校创新基金(2021A-076,2023A-088);甘肃省科技计划(创新基地和人才计划)项目(21JR7RA561);敦煌医学与转化教育部重点实验室开放基金项目(DHYX20-16);甘肃省中医药研究中心专项开放课题(zyzx-2020-zx10);甘肃省自然科学基金(21JR1RA267,22JR5RA582);甘肃省教育科技创新项目(2022A-067)。

摘　　要：骨质疏松症已逐渐成为一个重大的医疗和社会经济问题,其典型特征包括骨密度下降、骨微结构损坏以及骨折风险的增加。现有的治疗策略主要集中在症状管理上,但其并未能从根本上改变病情的发展趋势。因此,寻找并开发针对新的治疗靶点是更有效的治疗策略,已经成为当前研究的重要方向。P2X7作为一种由胞外ATP激活的离子通道,在近年的研究中已证实其在骨形成细胞和骨吸收细胞的生长、功能和存活方面发挥了关键作用,对于骨质疏松症的治疗具有巨大的潜力。因此,P2X7有望成为骨质疏松症治疗的新靶点。笔者对P2X7在骨质疏松症中的作用以及如何针对这一新靶点的治疗进行综述,旨在为开发新的骨质疏松症治疗策略提供新的思路和方向。Osteoporosis,characterized by decreased bone density,impaired bone microstructure,and increased risk of fractures,has gradually become a significant medical and socio-economic problem.Current treatment strategies primarily focus on symptom management but have not been able to fundamentally alter the course of the disease.Therefore,the search for and development of new therapeutic targets have emerged as an important direction in current research.P2X7,as an ion channel activated by extracellular ATP,has been found to play a crucial role in the growth,function,and survival of osteoblasts and osteoclasts in recent studies,holding immense potential for the treatment of osteoporosis.Consequently,P2X7 is poised to become a novel therapeutic target for osteoporosis.This review examines the role of P2X7 in osteoporosis and provides insights and directions for targeting this new therapeutic target,aiming to pave the way for the development of novel treatment strategies for osteoporosis.

关 键 词：P2X7 骨质疏松 破骨细胞 成骨细胞 

分 类 号：R589[医药卫生—内分泌]