Sequential enantioselective Ugi-4CR/post-Ugi transformation strategy:a precise construction of structurally diverse azaspiro polycyclic scaffolds  

作　　者：Xiao-Bao Wu Jun-Xiu Shi Yi-Ming Ou Hua-Jie Jiang Yi-Jun Fang Qi-Ming Wang Quan Gao Jie Yu 

机构地区：[1]Department of Applied Chemistry,Anhui Province Engineering Laboratory for Green Pesticide Development and Application,Anhui Province Key Laboratory of Crop Integrated Pest Management,Anhui Agricultural University,Hefei,230036,China

出　　处：《Science China Chemistry》2024年第2期576-586,共11页中国科学（化学英文版）

基　　金：supported by the National Natural Science Foundation of China (92156022);the Anhui Provincial Natural Science Funds (1908085J07,1908085QB79,2308085MB44,2308085QB44);the Shen-Nong Scholar Program of Anhui Agricultural University。

摘　　要：A privileged strategy has been developed for the precise construction of enantioenriched azaspiro polycyclic scaffolds.Structurally diverse azaspiro polycycles bearing multiple contiguous stereocenters are obtained with excellent results(up to 99:1 e.r.,>95:5 d.r.) via sequential enantioselective four-component Ugi reactions/post-Ugi transformations with substrates containing prerequisite functional groups in the presence of anionic stereogenic-at-cobalt(Ⅲ) complexes.

关 键 词：asymmetric catalysis post-Ugi transformation anionic stereogenic-at-cobalt(Ⅲ)complex azaspiro polycyclic scaffold one-pot synthesis 

分 类 号：O621.251[理学—有机化学]