钛植入物表面抗菌涂层的研究进展  

Progress in antibacterial coatings of titanium implants surfaces

作　　者：贺旭宏 郭柴琼 刘轩妤 王玉辉 梁紫微 连小洁 胡银春[1,2] 黄棣(综述) 魏延(审校)[1,2] HE Xuhong;GUO Chaiqiong;LIU Xuanyu;WANG Yuhui;LIANG Ziwei;LIAN Xiaojie;HU Yinchun;HUANG Di;WEI Yan(Department of Biomedical Engineering,College of Biomedical Engineering,Taiyuan University of Technology,Research Center for Nanobiomaterials and Regenerative Medicine,Taiyuan 030024,P.R.China;Institute of Biomedical Engineering,Taiyuan University of Technology,Taiyuan 030024,P.R.China)

机构地区：[1]太原理工大学生物医学工程学院生物医学工程系纳米生物材料与再生医学研究中心,太原030024 [2]太原理工大学生物医学工程研究所,太原030024

出　　处：《生物医学工程学杂志》2024年第1期191-198,共8页Journal of Biomedical Engineering

基　　金：国家自然科学基金项目(12272253,82103147,12202302);山西省应用基础研究计划项目(202203021221047,20210302124007,20210302124405);山西省回国留学人员科研资助项目(HGKY2019037)。

摘　　要：近年来,钛及钛合金等骨植入材料以其卓越的机械性能和良好的生物相容性广泛应用于生物医学领域。然而在临床实践中,细菌在材料表面的黏附以及术后感染问题可能导致植入失败。根据抗菌机制,本文从抗细菌黏附、接触杀菌和光控杀菌等方面详细阐述了钛植入物的抗菌表面设计。通过采用不同技术对钛或基于钛的合金植入物进行表面修饰,抑制细菌黏附并促进骨整合,将扩大多功能钛基植入物在骨科领域的应用范围。In recent years,bone implant materials such as titanium and titanium alloys have been widely used in the biomedical field due to their excellent mechanical properties and good biocompatibility.However,in clinical practice,bacterial adhesion to the material surface and postoperative infection issues may lead to implantation failure.Based on the antibacterial mechanism,this review elaborated on the antibacterial surface design of titanium implants from the aspects of anti-bacterial adhesion,contact sterilization and photocontrol sterilization.Surface modification of titanium or titanium-based alloy implants with different techniques can inhibit bacteria and promote osseointegration.Thus,the application range of multifunctional titanium-based implants in the field of orthopedics will be expanded.

关 键 词：钛植入物 生物相容性 抗菌能力 金属离子抗菌 

分 类 号：R318.08[医药卫生—生物医学工程]