基于线粒体自噬障碍探讨冠心病“阳微阴弦”的科学内涵  

Scientific Connotation of"Yang Wei Yin Xian"in Coronary Heart Disease Based on Mitophagy Disorder

作　　者：潘婷婷 宋子贤 赵晗[1] 周倩倩 张泽[2] PAN Tingting;SONG Zixian;ZHAO Han;ZHOU Qianqian;ZHANG Ze(Liaoning University of Traditional Chinese Medicine,Shenyang Liaoning China 110847;The Affiliated Hospital to Liaoning University of Traditional Chinese Medicine,Shenyang Liaoning China 110032)

机构地区：[1]辽宁中医药大学,辽宁沈阳110847 [2]辽宁中医药大学附属医院,辽宁沈阳110032

出　　处：《中医学报》2024年第3期463-467,共5页Acta Chinese Medicine

基　　金：国家中医药管理局重点学科基金项目;沈阳市科技局公共卫生研发专项项目(20-205-4-080)。

摘　　要：“阳微阴弦”是冠状动脉粥样硬化性心脏病(简称“冠心病”)的主要病机,阳气虚衰、痰瘀互结是贯穿疾病始终的病机特点。线粒体自噬障碍与冠心病的发病密切相关,线粒体自噬障碍不仅降低动脉血管弹性和斑块稳定性,而且加速血管平滑肌细胞及心肌细胞凋亡。线粒体自噬障碍与阳气虚衰相似,即“阳微”。阳气虚衰日久,痰瘀内生,即“阴弦”,与线粒体自噬障碍引起的代谢废物蓄积相似。故线粒体自噬障碍是“阳微”的微观病理基础,是“阴弦”的关键病理环节。"Yang Wei Yin Xian"is the main pathogenesis of coronary atherosclerotic heart disease(hereinafter referred to as"coronary heart disease"),in which process phlegm-blood stasis caused by Yang Qi deficiency exist throughout the disease.Mitochondrial autophagy disorder is closely related to the pathogenesis of coronary heart disease,which not only reduces arterial vascular elasticity and plaque stability but also accelerates apoptosis of vascular smooth muscle cells and cardiomyocytes.Mitophagy disorder is similar to Yang Qi deficiency,i.e.,"Yang Wei".Phlegm-blood stasis are induced by Yang Qi deficiency for a long time,which considered as"Yin Xian",being similar to the accumulation of metabolic waste caused by mitochondrial autophagy disorder.Therefore,mitophagy disorder is the microscopic pathological basis of"Yang Wei",and it is the key pathological step of"Yin Xian".

关 键 词：冠心病 “阳微阴弦” 线粒体自噬 阳气虚衰 痰瘀互结 痰浊 瘀血 

分 类 号：R256.22[医药卫生—中医内科学]