小青龙汤及其类方治疗支气管哮喘研究进展  

Research Progress on Treatment of Bronchial Asthma with Xiao Qinglong Decoction and Similar Prescriptions

作　　者：杜廷钰 孟泳 DU Tingyu;MENG Yong(Henan University of Chinese Medicine,Zhengzhou Henan China 450046;The Second Affiliated Hospital to Henan University of Chinese Medicine/Henan Provincial Hospital of Chinese Medicine,Zhengzhou Henan China 450002)

机构地区：[1]河南中医药大学,河南郑州450046 [2]河南中医药大学第二附属医院/河南省中医院,河南郑州450002

出　　处：《中医学报》2024年第3期570-576,共7页Acta Chinese Medicine

基　　金：河南省中医药科学研究项目(20-21ZY2200,2023ZY3008)。

摘　　要：小青龙汤、射干麻黄汤及大青龙汤治疗支气管哮喘等呼吸系统疾病疗效显著,不良反应较少,相关文献研究、临床研究及基础研究表明小青龙汤及其类方能够有效减少哮喘发作次数,改善患者肺功能检查指标等,主要是通过降低炎症因子水平、抑制气道重塑、改善肺部及气道病理组织以及增强机体免疫功能等实现的。现有研究仍存在临床研究较少、作用机制匮乏等不足,今后需进一步加强哮喘疾病的流行病学研究,加强中医药治疗哮喘大样本、多中心的临床试验研究,完善疗效评价标准;加强对中医药多成分、多靶点、多通路的相关技术分析;从宏观及微观角度探讨中医药治疗哮喘疾病的作用机制,以期对中医药治疗哮喘疾病的探索提供理论依据。Xiao Qinglong decoction,Shegan Mahuang Decoction and Da Qinglong Decoction have significant efficacy in the treatment of bronchial asthma and other respiratory diseases,with few adverse reactions.Relevant literature research,clinical research and basic studies have shown that Xiao Qinglong Decoction and its similar formulas can effectively reduce the number of asthma attacks and improve the pulmonary function test indicators of patients,mainly by reducing the level of inflammatory factors,inhibiting airway remodeling,improving lung and airway pathological tissues,and enhancing the body′s immune function.In the future,it is necessary to further strengthen the epidemiological research on asthma diseases,strengthen the small number of large-sample and multi-center clinical trial studies on the treatment of asthma with traditional Chinese medicine,and improve the efficacy evaluation standards.Strengthen the technical analysis of multi-component,multi-target and multi-pathway in traditional Chinese medicine.To explore the mechanism of action of traditional Chinese medicine in the treatment of asthma from the macro and micro perspectives,in order to provide guidance for the exploration and application of traditional Chinese medicine in the treatment of asthma.

关 键 词：支气管哮喘 小青龙汤 类方 射干麻黄汤 大青龙汤 气道重塑 

分 类 号：R256.12[医药卫生—中医内科学]