双盐洗鼻剂鼻腔冲洗用于慢性鼻窦炎鼻窦内镜术后临床疗效及对血清炎症因子、疼痛视觉模拟评分的影响  

Clinical curative effect of double-salt collunarium for nasal wash and its influence on serum inflammatory factors and VAS scores in chronic rhinosinusitis after sinus endoscopy

作　　者：王秋丰 范学洋 王若琳 WANG Qiu-feng;FAN Xue-yang;WANG Ruo-lin(Department of Otolaryngology,Tangshan Central Hospital,Tangshan 063000,China)

机构地区：[1]唐山中心医院耳鼻喉科,河北唐山063000

出　　处：《中国药物应用与监测》2023年第4期246-249,共4页Chinese Journal of Drug Application and Monitoring

摘　　要：目的:探究双盐洗鼻剂鼻腔冲洗用于慢性鼻窦炎(CRS)鼻窦内窥镜术后临床疗效及对血清炎症因子、疼痛视觉模拟量表(VAS)评分的影响。方法:选择2020年3月至2023年5月于唐山中心医院接受鼻窦内镜术的112例CRS患者为研究对象。以随机双盲法分为对照组和观察组,每组56例,对照组患者于术后接受300 mL 3%高渗盐水等常规治疗,观察组患者术后联合双盐洗鼻剂鼻腔冲洗治疗。比较两组患者疗效,并分析两组患者治疗前后血清炎性因子、围手术期生活质量(SNOT-20)和VAS评分。结果:治疗后,与对照组总有效率82.14%比较,观察组总有效率94.64%更高,差异有统计学意义(P<0.05);治疗后,观察组治疗后1、2个月的VAS评分[(5.84±1.89)分、(3.98±1.26)分]、SNOT-20评分[(2.77±0.41)分]以及IL-5[(3.28±0.94)ng·mL^(-1)]和IL-6[(85.12±11.24)ng·L^(-1)],低于对照组的[(6.71±1.64)分、(5.12±1.17)分、(4.45±0.72)分、(5.78±1.23)ng·mL^(-1)、(60.84±5.20)ng·L^(-1)],差异有统计学意义(P<0.05);治疗期间,两组患者不良反应事件发生率分别为12.50%、5.36%,差异无统计学意义(P>0.05)。结论:双盐洗鼻剂鼻腔冲洗用于CRS患者鼻窦内镜术后治疗,可显著提升CRS患者疗效,改善疼痛症状和生活质量,稳定患者机体内血清炎性因子水平。Objective:To investigate the clinical curative effect of double-salt collunarium for nasal wash and its influence on serum inflammatory factors and scores of visual analogue scale(VAS)in chronic rhinosinusitis(CRS)after sinus endoscopy.Methods:A total of 112 patients with CRS undergoing sinus endoscopy in our hospital from March 2020 to May 2023 were enrolled in this study.According to random double-blind method,they were divided into the control group and observation group,with 56 in each.After surgery,patients in the control group were given routine treatment(300 mL of 3%hypertonic saline),while those in the observation group were additionally treated with double-salt collunarium(iodine-free sea salt+sodium bicarbonate)for nasal wash.The curative effect in the two groups was compared.The levels of serum inflammatory factors,scores of sinonasal outcome test-20(SNOT-20)and VAS in the 2 groups were analyzed before and after treatment.Results:After treatment,total response rate was higher in the observation group than in the control(94.64%vs 82.14%,P<0.05).The scores of VAS[(5.84±1.89)points,(3.98±1.26)points]at 1 month and 2 months after treatment,SNOT-20 score[(2.77±0.41)points],levels of IL-5[(3.28±0.94)ng·mL^(-1)]and IL-6[(85.12±11.24)ng·L^(-1)]L in the observation group were significantly lower than those in the control[(6.71±1.64)points,(5.12±1.17)points,(4.45±0.72)points,(5.78±1.23)ng·mL^(-1),(60.84±5.20)ng·L^(-1)],the differences were statistically significant(P<0.05).During treatment,there was no significant difference in incidence of adverse reactions between the two groups(12.50%vs 5.36%,P>0.05).Conclusion:Double-salt collunarium for nasal wash can significantly promote curative effect,improve pain symptoms and quality of life,and stabilize levels of serum inflammatory factors in patients with CRS after sinus endoscopy.

关 键 词：慢性鼻窦炎 鼻窦内镜术 双盐洗鼻剂 鼻腔冲洗 临床疗效 血清炎症因子、视觉模拟量表评分 

分 类 号：R765.4[医药卫生—耳鼻咽喉科]