血浆Hcy、D-二聚体、Lp(a)、25(OH)D水平与老年冠心病患者病情严重程度及心功能分级的相关性  

Correlations among plasma Hcy,D-dimer,Lp(a),25(OH)D levels and severity of coronary heart disease and cardiac function classification in elderly patients with coronary heart disease

作　　者：贾梅香[1] JIA Meixiang(Xinxiang Central Hospital,Xinxiang 453500 Henan,China)

机构地区：[1]新乡市中心医院检验科,河南新乡453500

出　　处：《中国民康医学》2024年第4期130-133,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察血浆同型半胱氨酸(Hcy)、D-二聚体、脂蛋白a[Lp(a)]及25羟维生素D[25(OH)D]水平与老年冠心病患者病情严重程度及心功能分级的相关性。方法:选取2021年2月至2022年2月该院收治的100例老年冠心病患者进行横断面研究,设为冠心病组。另选取同期100名健康体检者进行横断面研究,设为健康组。比较两组血浆Hcy、D-二聚体、Lp(a)及25(OH)D水平;比较冠心病组不同病情严重程度、不同心功能分级患者的血浆Hcy、D-二聚体、Lp(a)及25(OH)D水平;采用Spearman相关性分析,分析血浆Hcy、D-二聚体、Lp(a)及25(OH)D水平与冠心病患者病情程度、心功能分级的相关性。结果:冠心病组血浆Hcy、D-二聚体、Lp(a)水平均高于健康组,血浆25(OH)D水平低于健康组,差异有统计学意义(P<0.05)。重度冠心病患者血浆Hcy、D-二聚体、Lp(a)水平高于中度和轻度患者,且中度患者高于轻度患者;重度冠心病患者血浆25(OH)D水平低于中度和轻度患者,且中度患者低于轻度患者,差异均有统计学意义(P<0.05)。纽约心脏病学会(NYHA)心功能分级Ⅳ级冠心病患者血浆Hcy、D-二聚体、Lp(a)水平高于Ⅲ级、Ⅱ级患者,且Ⅲ级患者高于Ⅱ级患者;NYHA心功能分级Ⅳ级冠心病患者血浆25(OH)D水平低于Ⅲ级、Ⅱ级患者,且Ⅲ级患者低于Ⅱ级患者,差异均有统计学意义(P<0.05)。Spearman相关性分析结果显示,血浆Hcy、D-二聚体、Lp(a)水平与冠心病患者病情严重程度、心功能分级均呈正相关(r>0,P<0.05);血浆25(OH)D水平与冠心病患者病情严重程度、心功能分级均呈负相关(r<0,P<0.05)。结论:血浆Hcy、D-二聚体、Lp(a)水平与老年冠心病患者病情严重程度、心功能分级均呈正相关,血浆25(OH)D水平与老年冠心病患者病情严重程度、心功能分级均呈负相关。Objective:To observe correlations among plasma homocysteine(Hcy),D-dimer,lipoprotein a[Lp(a)],25-hydroxy vitamin D[25(OH)D]levels and severity of coronary heart disease and cardiac function classification in elderly patients with coronary heart disease.Methods:A cross-sectional study was conducted on 100 elderly patients with coronary heart disease admitted to the hospital from February 2021 to February 2022,and they were set as the coronary heart disease group.In addition,100 healthy subjects were selected for the cross-sectional study and set as healthy group.The levels of plasma Hcy,D-dimer,Lp(a)and 25(OH)D were compared between the two groups.The levels of plasma Hcy,D-dimer,Lp(a)and 25(OH)D in the patients with different severity and different cardiac function classifications in the coronary heart disease group were compared.Spearman correlation analysis was used to analyze the correlations among the plasma Hcy,D-dimer,Lp(a)and 25(OH)D levels and the severity of coronary heart disease and cardiac function classification.Results:The levels of plasma Hcy,D-dimer and Lp(a)in the coronary heart disease group were higher than those in the healthy group,the level of plasma 25(OH)D was lower than that in the healthy group,and the differences were statistically significant(P<0.05).The levels of plasma Hcy,D-dimer and Lp(a)in the patients with severe coronary heart disease were higher than those in the moderate and mild patients,and those in the moderate patients were higher than those in the mild patients;the levels of plasma 25(OH)D in the patients with severe coronary heart disease were lower than those in the moderate and mild patients,and that in the moderate patients was lower than that in the mild patients;and the differences were statistically significant(P<0.05).The levels of plasma Hcy,D-dimer and Lp(a)in the patients with coronary heart disease of New York Heart Association(NYHA)cardiac function classification IV were higher than those in patients with classification III and classification II,and those in

关 键 词：老年 冠心病 病情严重程度 HCY D-二聚体 Lp(a) 25(OH)D 相关性 

分 类 号：R541.4[医药卫生—心血管疾病]