脑钠肽、血管紧张素Ⅱ、血浆蛋白C在老年冠心病中的表达及临床检测价值探究  

Expression and clinical detection value of brain natriuretic peptide,angiotensinⅡ,and plasma protein C in elderly patients with coronary heart disease

作　　者：韩晓霞 赵志杰 李鹏飞 刘青 HAN Xiaoxia;ZHAO Zhijie;LI Pengfei;LIU Qing(Department of Clinical Laboratory,Cangzhou People’s Hospital,Hebei Province,Cangzhou 061000,China)

机构地区：[1]河北省沧州市人民医院检验科,河北沧州061000

出　　处：《中国医药导报》2024年第5期78-81,104,共5页China Medical Herald

基　　金：河北省卫生健康委科研基金项目课题(20220323)。

摘　　要：目的探究脑钠肽(BNP)、血管紧张素Ⅱ(AngⅡ)、血浆蛋白C(PC)在老年冠心病中的表达及临床检测价值。方法选取2021年1月至2023年1月河北省沧州市人民医院收治的78例经冠脉造影检查确诊的老年冠心病患者,作为研究组。其中稳定型心绞痛27例,不稳定型心绞痛31例,心肌梗死20例。稳定型心绞痛表现发作时心电图ST段有压低。不稳定型心绞痛表现发作时心电图暂时性ST段压低>1 mm,发作缓解后恢复或接近正常,心肌损伤标志物无明显升高。心肌梗死表现为持续性胸痛>30 min,有典型心肌损伤坏死的动态心电图变化。再选取同期体检健康人群60名为对照组。比较两组临床资料、BNP、AngⅡ、PC水平及临床检测价值。结果研究组BNP、AngⅡ水平高于对照组,PC水平低于对照组,差异有统计学意义(P<0.05)。心肌梗死组BNP、AngⅡ水平高于稳定型心绞痛组和不稳定型心绞痛组,PC水平明显低于稳定型心绞痛组和不稳定型心绞痛组,差异有统计学意义(P<0.05)。BNP、AngⅡ在老年冠心病中呈正相关(r>0,P<0.05),BNP、PC在老年冠心病中呈负相关(r<0,P<0.05),AngⅡ、PC在老年冠心病呈负相关(r<0,P<0.05)。三者联合检测的灵敏度、特异度和准确度均较高于BNP、AngⅡ、PC单项检测,对老年冠心病患者检出率较高。结论BNP、AngⅡ、PC在老年冠心病中的表达明显,BNP、AngⅡ、PC作为老年冠心病临床诊断的检测指标有一定效果,值得临床推广应用。Objective To investigate the expression and clinical value of brain natriuretic peptide,angiotensinⅡ,and plasma protein C(BNP),(AngⅡ)and plasma protein C(PC)in elderly patients with coronary heart disease.Methods A total of 78 elderly patients with coronary heart disease diagnosed by coronary angiography in Cangzhou People’s Hospital of Hebei Province from January 2021 to January 2023 were selected as the study group.Among them,27 cases with stable angina pectoris.31 cases with unstable angina pectoris,20 cases with myocardial infarction.Stable angina pectoris presents with ST segment depression.In unstable angina pectoris,the transient ST segment depression of ECG was more than 1 mm,which recovered or was close to normal after remission,and the markers of myocardial damage were not significantly increased.The myocardial infarction was characterized by persistent chest pain>30 min and dynamic electrocardiogram changes with typical myocardial injury and necrosis.Then 60 healthy people were selected as control group.The clinical data,levels of BNP,AngⅡ,PC,and clinical detection value of the two groups were compared.Results The levels of BNP and AngⅡin the study group were higher than those in the control group,and the level of PC was lower than that in the control group,the differences were statistically significant(P<0.05).BNP and AngⅡlevels in myocardial infarction group were higher than those in stable angina pectoris and unstable angina pectoris groups,and PC levels were significantly lower than those in stable angina pectoris and unstable angina pectoris groups,the differences were statistically significant(P<0.05).In elderly patients with coronary heart disease,BNP was positively correlated with AngⅡ(r>0,P<0.05),BNP was negatively correlated with PC(r<0,P<0.05),and AngⅡwas negatively correlated with coronary heart disease in the elderly PC(r<0,P<0.05).The sensitivity,specificity and accuracy of the three combined tests were higher than that of BNP,AngⅡand PC,and the detection rate of elderly

关 键 词：老年冠心病 脑钠肽 血管紧张素Ⅱ 血浆蛋白C 

分 类 号：R541.6[医药卫生—心血管疾病]