双水平气道正压通气呼吸机辅助冻干重组人脑钠肽对肺心病患者的影响  

Effect of lyophilized recombinant human brain natriuretic peptide assisted by bilevel positive airway pressure ventilator on patients with pneumocardial disease

作　　者：李娜 房洁 LI Na;FANG Jie(Department of Respiratory Medicine,the 960th Hospital of the Chinese People’s Liberation Army Joint Logistic Support Force,Shandong Province,Jinan 250031,China;Department of Cardiovascular Medicine,the 960th Hospital of the Chinese People’s Liberation Army Joint Logistic Support Force,Shandong Province,Jinan 250031,China)

机构地区：[1]中国人民解放军联勤保障部队第九六〇医院呼吸科,山东济南250031 [2]中国人民解放军联勤保障部队第九六〇医院心血管内科,山东济南250031

出　　处：《中国医药导报》2024年第5期127-130,共4页China Medical Herald

基　　金：山东省中医药科技发展计划重点基金项目(2020Z04)。

摘　　要：目的探讨双水平气道正压通气(BPAP)呼吸机辅助冻干重组人脑钠肽对肺心病患者的影响。方法纳入中国人民解放军联勤保障部队第九六〇医院2020年10月至2022年10月收治的肺心病患者236例,采用随机数字表法将其分为对照组(118例)与试验组(118例)。对照组给予冻干重组人脑钠肽治疗,试验组给予BPAP呼吸机辅助冻干重组人脑钠肽治疗,两组均治疗10 d。比较两组临床疗效,检测两组治疗前后心功能、肺功能、血气指标,记录两组不良反应。结果试验组疗效优于对照组,差异有统计学意义(P<0.05)。治疗后,两组每搏输出量(SV)、左室射血分数(LVEF)高于治疗前,N-末端脑钠肽前体(NT-proBNP)低于治疗前,且试验组SV、LVEF高于对照组,NT-proBNP低于对照组,差异有统计学意义(P<0.05)。治疗后,两组第1秒用力呼气容积占预计值百分比(FEV1%)、FEV1/用力肺活量(FVC)、动脉血氧分压(PaO_(2))高于治疗前,动脉血二氧化碳分压(PaCO_(2))低于治疗前,且试验组FEV1%、FEV1/FVC、PaO_(2)高于对照组,PaCO_(2)低于对照组,差异有统计学意义(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论BPAP呼吸机辅助冻干重组人脑钠肽对肺心病有较好的疗效,可改善患者心肺功能及动脉血气指标。Objective To investigate the effect of lyophilized recombinant human brain natriuretic peptide assisted by bilevel positive airway pressure(BPAP)ventilator on patients with pneumocardial disease.Methods A total of 236 patients with pneumocardial disease admitted to the 960th Hospital of the Chinese People’s Liberation Army Joint Logistic Support Force from October 2020 to October 2022 were divided into control group(118 cases)and experimental group(118 cases)by random number table method.The control group was treated with lyophilized recombinant human brain natriuretic peptide,and the experimental group was treated with BPAP ventilator assisted lyophilized recombinant human brain natriuretic peptide.Both groups were treated for ten days.The clinical efficacy of the two groups was compared,the indexes of heart function,lung function,and blood gas before and after treatment were detected,and the adverse reactions of the two groups were recorded.Results The curative effect of the experimental group was better than that of the control group,and the difference was statistically significant(P<0.05).After treatment,stroke volume(SV)and left ventricular ejection fraction(LVEF)in two groups were higher than those before treatment,N-terminal brain natriuretic peptide precursor(NT-proBNP)was lower than that before treatment,and SV and LVEF in experimental group were higher than those in the control group,and NT-proBNP was lower than that in the control group,the differences were statistically significant(P<0.05).After treatment,the percentage of forced expiratory volume in one second to the expected value(FEV1%),FEV1/forced vital capacity(FVC),and partial pressure of oxygen in arterial blood(PaO_(2))in the two groups were higher than those before treatment,and the partial pressure of carbon dioxide in arterial blood(PaCO_(2))was lower than that before treatment,and the FEV1%,FEV1/FVC,and PaO_(2) in the experimental group were higher than those in the control group,PaCO_(2) was lower than that in the control group,the diff

关 键 词：肺心病 双水平气道正压通气 冻干重组人脑利钠肽 心功能 

分 类 号：R563[医药卫生—呼吸系统]