通天口服液治疗脑梗死恢复期瘀血阻络挟风证的安全性与有效性  

Safety and Effectiveness of Tongtian Oral Liquid for the Treatment of Convalescent Cerebral Infarction with Syndrome of Blood Stasis Blocking Collaterals and Wind Entrainment

作　　者：邓楚珺 孟胜喜[1] 徐卿[1] 陈慧泽 王兵[1] 谈世进[1] 付剑亮[1] DENG Chujun;MENG Shengxi;XU Qing;CHEN Huize;WANG Bing;TAN Shijin;FU Jianliang(Shanghai Sixth People′s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200233,China)

机构地区：[1]上海交通大学医学院附属第六人民医院,上海200233

出　　处：《中西医结合心脑血管病杂志》2024年第5期806-810,共5页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

基　　金：上海市第六人民医院医疗服务能级提升工程临床医疗技术骨干队伍培育项目(No.20220213);上海市科委中医引导类项目(No.19401932500);上海市第六人民医院2022年度抗击新冠肺炎疫情应急专题项目(No.ynxg202218);上海市进一步加快中医药传承创新发展三年行动计划(2021—2023年)项目[No.ZY(2021-2023)-0205-04];华东片区及市级中医专科专病联盟建设项目[No.ZY(2021-2023)-0302]。

摘　　要：目的:观察通天口服液治疗脑梗死恢复期瘀血阻络挟风证的安全性与有效性。方法:选取2020年1月—2022年1月上海市第六人民医院治疗的脑梗死恢复期瘀血阻络挟风证病人185例,采用随机数字表法将病人分为观察组和对照组。对照组予以常规治疗,观察组在常规治疗基础上予以通天口服液治疗,两组疗程均为8周。记录两组研究期间不良反应发生情况。疗程结束后,比较两组临床疗效、安全性及治疗前后两组血清神经营养因子(NTF)、神经元特异性烯醇化酶(NSE)、髓鞘碱性蛋白(MBP)、神经生长因子(NGF)、脑源性神经营养因子(BDNF)及超敏C反应蛋白(hs-CRP)、白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)炎性因子水平。结果:治疗后,观察组总有效率为92.86%,对照组为74.23%,两组比较差异有统计学意义(P<0.05)。治疗后,观察组血清NTF、BDNF及NGF水平较治疗前升高,血清NSE、MBP水平较治疗前下降,且观察组治疗后血清NTF、BDNF及NGF水平高于对照组,血清NSE、MBP水平低于对照组,差异均有统计学意义(P<0.05或P<0.01)。治疗后,观察组血清炎性因子hs-CRP、IL-1β、IL-6及TNF-α水平均较治疗前下降,且观察组治疗后血清hs-CRP、IL-1β、IL-6及TNF-α水平低于对照组,差异均有统计学意义(P<0.05)。观察组不良反应发生率为3.06%,对照组为2.06%,两组比较差异无统计学意义(P>0.05)。结论:通天口服液可改善脑梗死恢复期瘀血阻络挟风证病人症状,显著提高临床疗效,且安全性较高,其作用机制可能与升高血清神经因子NTF、BDNF及NGF水平,降低血清神经因子NSE、MBP水平及血清炎性因子hs-CRP、IL-1β、IL-6、TNF-α水平有关。Objective:To explore the safety and effectiveness of Tongtian Oral Liquid for the treatment of convalescent cerebral infarction with syndrome of blood stasis blocking collaterals and wind entrainment.Methods:One hundred and eighty-five patients of cerebral infarction patients with syndrome of blood stasis blocking and wind entrainment were randomly divided into the observation group and control group.The patients in the control group were treated with conventional treatment for 8 weeks,and the patients in the observation group was treated with Tongtian Oral Liquid on the basis of conventional treatment for 8 weeks.Adverse events during the study period were recorded in both groups.After treatment,the clinical efficacy,safety,serum neurotrophic factor(NTF),neuron-specific enolase(NSE),myelin basic protein(MBP),nerve growth factor(NGF),brain-derived neurotrophic factor(BDNF),hypersensitive C-reactive protein(hs-CRP)and interleukin-1β(IL-1β),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)and other inflammatory factors were compared between the two groups before and after treatment.Results:The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(92.86%vs 74.23%,P<0.05).After treatment,the levels of serum NTF,BDNF and NGF in the observation group were higher than that before treatment,while the levels of serum NSE and MBP were lower than that before treatment(P<0.05).The levels of serum NTF,BDNF and NGF in the observation group were higher than those in the control group,while the levels of serum NSE and MBP were lower than those in the control group(P<0.05 or P<0.01).After treatment,the levels of serum inflammatory factors hs-CRP,IL-1β,IL-6,and TNF-αin the observation group decreased,and the levels of serum hs-CRP,IL-1β,IL-6,and TNF-αin the observation group were lower than those in control group(P<0.05).The incidence of adverse reactions was 3.06%in the observation group and 2.06%in the control group,without statistical si

关 键 词：脑梗死恢复期 通天口服液 瘀血阻络挟风证 神经细胞因子 炎性因子 

分 类 号：R277.7[医药卫生—中医学]