自拟清热消癜汤辅助西药治疗儿童过敏性紫癜的疗效及对临床症状、肾功能指标和免疫功能的影响  

The Effect of Self formulated Qingre Xiaodian Tang on Clinical symptoms,renal function indicators,and immune function in children with allergic purpura treated with Western medicine

作　　者：李洁[1] 邵盛春 LI Jie;SHAO Shengchun(Pharmacy Department of Luzhou People’s Hospital,Luzhou Sichuan 646000,China;Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University,Luzhou Sichuan 646000,China)

机构地区：[1]泸州市人民医院药学部,四川泸州646000 [2]西南医科大学附属中医院,四川泸州646000

出　　处：《四川中医》2023年第12期93-96,共4页Journal of Sichuan of Traditional Chinese Medicine

摘　　要：目的:探究自拟清热消癜汤辅助西药治疗儿童过敏性紫癜的疗效及对临床症状、肾功能指标和免疫指标的影响。方法:选择2020年8月~2022年9月期间某院儿童过敏性紫癜病例90例,按照随机数字表法分为对照组与观察组,两组受试对象均为45名。对照组采用西药对症治疗,观察组在对照组西药治疗的基础上额外使用自拟清热消癜汤进行辅助治疗。治疗完成后评估两组患儿疗效的差异,比较治疗前与治疗后两组患儿中医证候积分、肾功能水平、免疫功能水平的变化,分析两组患儿治疗期间发生药品不良反应的差异。结果:治疗完成后,观察组患儿总有效率高于对照组(P<0.05);两组患儿紫癜、关节肿痛、腹痛、口渴、便秘得分均较治疗前降低,且观察组上述5项中医证候积分低于对照组(P均<0.05);两组患儿的24h尿蛋白定量、尿β_(2)微球蛋白(β_(2)-MG)、IgE、IgA、IgM水平均明显较治疗前降低,且观察组的上述指标均显著低于对照组(P均<0.05);两组患儿的尿微量白蛋白(ALB)均较治疗前上升,且观察组明显高于对照组(P<0.05);治疗期间,对照组与观察组患儿分别发生2例、1例药品不良反应,差异无统计学意义(P>0.05)。结论:自拟清热消癜汤辅助西药治疗儿童过敏性紫癜有助于疗效提升,且对临床症状、肾功能、免疫功能的调节效果更显著。Objective:To explore the effect of self formulated Qingre Xiaodian Tang on clinical symptoms,renal function indicators,and immune indicators in children with allergic purpura treated with Western medicine.Method:90 cases of allergic purpura in children from a certain hospital from August 2020 to September 2022 were selected and randomly divided into a control group and an observation group,with 45 subjects in both groups.The control group received symptomatic treatment with Western medicine,while the observation group received additional treatment with self-designed Qing Re Xiao Dian Tang on the basis of Western medicine treatment in the control group.After the completion of treatment,evaluate the differences in the efficacy of the two groups of children,compare the changes in traditional Chinese medicine syndrome scores,renal function levels,and immune function levels of the two groups of children before and after treatment,and analyze the differences in adverse drug reactions between the two groups of children during treatment.Result:After treatment,the total effective rate of the observation group was higher than that of the control group(P<0.05);The scores of purpura,joint swelling,abdominal pain,thirst,and constipation in both groups of children decreased compared to before treatment,and the observation group had lower scores of the above five traditional Chinese medicine syndromes than the control group(P<0.05);24-hour urine protein quantification and urine analysis of two groups of childrenβ_(2)microglobulin β.The levels of 2-MG,IgE,IgA,and IgM were significantly lower than before treatment,and the above indicators in the observation group were significantly lower than those in the control group(P<0.05);The urinary microalbumin(ALB)of both groups of children increased compared to before treatment,and the observation group was significantly higher than the control group(P<0.05);During the treatment period,the control group and the observation group had 2 and 1 cases of adverse drug reactions,respectively,

关 键 词：过敏性紫癜 自拟清热消癜汤 儿童 肾功能 免疫功能 

分 类 号：R554.6[医药卫生—血液循环系统疾病]