温灸配合“清消法”治疗肉芽肿性乳腺炎临床研究  

Clinical Study of Curative Effect on Warm Moxibustion Combined with“Qingxiao Method”in the Treatment of Granulomatous Mastitis

作　　者：郑懿 史有阳 郑金洲[1] 宋晓耘[1] 陈力新 杨剑锋[1] 高阳 刘舒月 刘胜[1] 周细秋[1] ZHENG Yi;SHI Youyang;ZHENG Jinzhou;SONG Xiaoyun;CHEN Lixin;YANG Jianfeng;GAO Yang;LIU Shuyue;LIU Sheng;ZHOU Xiqiu(Pudong Branch,Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200030,China)

机构地区：[1]上海中医药大学附属龙华医院浦东分院,上海200030

出　　处：《辽宁中医药大学学报》2024年第2期210-213,共4页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：上海市浦东新区卫健委卫生科技联合攻关项目(PW2022D-15);上海中医药大学附属龙华医院爱建捐赠基金项目(AJ047)。

摘　　要：目的观察外用温灸法配合顾氏外科“清消法”治疗肉芽肿性乳腺炎的临床疗效。方法临床收集90例符合肉芽肿性乳腺炎诊断标准的患者,每组各45例,实验组使用温灸配合“清消法”治疗,对照组单纯使用“清消法”治疗,疗程14 d,随访1个月,观察两组患者创面愈合情况及中医局部证候评分和肿瘤坏死因子-α(tumor necrosis factor,TNF-α)、白细胞介素-6(interleukin-6,IL-6)的差异情况。结果在14 d及30 d的观察节点中,实验组和对照组患者的创面面积较入组前均有明显缩小,差异有统计学意义(P<0.01),治疗30 d时,实验组创面面积为(18.16±4.66)mm^(2),优于对照组(20.91±4.79)mm^(2),差异有统计学意义(P<0.01)。治疗14 d、30 d时两组患者同时点比较,实验组患者中医局部证候评分均高于对照组,相较于对照组,实验组患者局部阴阳证候更倾向于保持在阳证的证候,两组数据比较差异有统计学意义(P<0.05);实验组IL-6表达显著低于对照组(P<0.05)。在治疗14 d及30 d时间节点,两组TNF-α指标差异均无统计学意义(P>0.05),但已整体呈现出明显的下降趋势。在治疗过程中,两组患者均无明显不良反应发生,对该疗法的耐受度好。结论使用温灸法配合顾氏外科“清消法”能缩短患乳创面愈合时间,且该疗法安全、操作简单,值得在临床上进行推广。Objective To observe the clinical effect of external moxibustion combined with GU's surgical“Qingxiao method”in the treatment of granulomatous mastitis.Methods 90 patients with granulomatous mastitis were collected clinically,45 in each group.The experimental group was treated with warm moxibustion combined with“Qingxiao method”,while the control group was treated with“Qingxiao method”alone.The course of treatment was 14 days,and the patients were followed up for 1 month.The wound healing,TCM local syndrome score and inflammatory factors TNF-αand IL-6 were observed in the two groups.Results At the observation nodes of 14 d and 30 d,the wound area of the experimental group and the control group patients significantly decreased compared to before enrollment,with a statistically significant difference(P<0.01),at 30 d of treatment,the wound area of the experimental group was(18.16±4.66)mm^(2),which was better than that of the control group(20.91±4.79)mm^(2),with a statistically significant difference(P<0.01).At the same time point comparison between the two groups of patients on the 14 d and 30 d of treatment,the local TCM syndrome scores of the experimental group were higher than those of the control group.Compared with the control group,the local Yin-Yang syndrome of the experimental group patients tended to maintain a positive syndrome,and the difference in data between the two groups was statistically significant(P<0.05);The expression of IL-6 in the experimental group was significantly lower than that in the control group(P<0.05).At the time points of 14 d and 30 d of treatment,there was no statistically significant difference between the two groups of TNF-αindicators(P>0.05),but showed a significant downward trend overall.During the treatment process,both groups of patients had no significant adverse reactions and had good tolerance to the therapy.Conclusion The use of warm moxibustion combined with GU's surgical“Qingxiao method”is better than the use of“Qingxiao method”alone in accelera

关 键 词：肉芽肿性乳腺炎 温灸法 顾氏外科“清消法” 煨脓长肉 

分 类 号：R271.44[医药卫生—中医妇科学]