肠道菌群和肠黏膜屏障在类风湿关节炎中的作用  

The role of intestinal flora and intestinal mucosal barrier in the occurrence and development of rheumatoid arthritis

作　　者：刘君 郝华 董秋梅 吴昊 LIU Jun;HAO Hua;DONG Qiumei;WU Hao(College of Traditional Chinese Medicine,Inner Mongolia Medical University,Hohhot,Inner Mongolia 010100,China)

机构地区：[1]内蒙古医科大学中医学院,内蒙古呼和浩特010100

出　　处：《中国微生态学杂志》2023年第12期1457-1460,共4页Chinese Journal of Microecology

基　　金：国家自然科学基金(81660836);内蒙古自然科学基金(2021MS08031,2023QN08041);内蒙古蒙医药协同创新中心项目(MYYXTPY202203);内蒙古医科大学校级项目(YKD2023MS090)。

摘　　要：类风湿关节炎(rheumatoid arthritis,RA)是一种自身免疫性疾病,致畸率与致残率较高,发病机制尚不清楚,目前尚未有特效药可完全治愈。近年来,国内外相关研究表明RA的发病机制与肠道菌群和肠黏膜屏障密切相关。积极调节肠道菌群和改善肠黏膜屏障可有效缓解RA的关节炎症状,这可能作为RA干预的新靶点。肠道菌群失调引起肠道微生态失衡,一系列有害物质侵入并诱发肠道炎症反应,导致肠道黏膜屏障功能障碍,可能参与RA的发病,但具体作用机制还需进一步明确。本文对肠道菌群和肠黏膜屏障在RA中的具体作用及影响进行总结归纳,以期为治疗RA提供新方向。Rheumatoid arthritis(RA)is an autoimmune disease with high rates of teratogenicity and disability,And its pathogenesis is not clear yet.At present,there is no specific drug to treat it completely.In recent years,relevant literature studies at home and abroad have shown that its pathogenesis is closely related to intestinal flora and intestinal mucosal barrier.Actively regulating intestinal flora and improving intestinal mucosal barrier can effectively alleviate the symptoms of RA,which may be a new target for intervention in RA.The imbalance of intestinal flora leads to the imbalance of intestinal microecology.A series of harmful substances invade and induce intestinal inflammatory responses,resulting in the dysfunction of intestinal mucosal barrier,which may be involved in the pathogenesis of RA,but the specific mechanism needs to be further clarified.This paper summarizes the specific role and influence of intestinal flora and intestinal mucosal barrier in RA,so as to provide a new direction for the treatment of RA.

关 键 词：肠道菌群 肠黏膜屏障 类风湿关节炎 作用 

分 类 号：R593.22[医药卫生—内科学]