血液透析联合血液灌流对伴肾性高血压尿毒症患者血压、血红蛋白及尿素清除指数的影响  

Effects of Hemodialysis Combined with Hemoperfusion on Blood Pressure,Hemoglobin and Urea Clearance Index in Uremic Patients with Renal Hypertension

作　　者：胡春艳 李惠[2] 牛聪 HU Chun-yan;LI Hui;NIU Cong(Department of Dialysis,The First Affiliated Hospital of Henan University,Kaifeng 475000,China;Department of Nephrology,The First Affiliated Hospital of Henan University,Kaifeng 475000,China)

机构地区：[1]河南大学第一附属医院透析室,开封475001 [2]河南大学第一附属医院肾病科,开封475001

出　　处：《四川解剖学杂志》2023年第4期52-54,共3页Sichuan Journal of Anatomy

基　　金：2018年河南省医学科技攻关计划项目(2018020323)资助。

摘　　要：目的:探讨血液透析联合血液灌流对伴肾性高血压尿毒症患者血压、血红蛋白及尿素清除指数(KT/V)的影响.方法:选取2020年4月至2022年3月本院收治的82例尿毒症伴肾性高血压患者为研究对象.采用随机数字表法将其分为观察组(n=42,血液透析联合血液灌流治疗)和对照组(n=40,仅血液透析治疗).比较两组患者透析前、后血压、血红蛋白、透析后KT/V及甲状旁腺激素(PTH)清除率和不良反应发生率.结果:两组患者透析后血压均有下降,血红蛋白均有上升,观察组的血压变化较大,且血红蛋白高于对照组,差异均有统计学意义(P<0.05).两组透析后KT/V值及PTH清除率比较,差异均无统计学意义(P>0.05).观察组患者不良反应的发生率明显低于对照组,差异有统计学意义(P<0.05).结论:血液透析联合血液灌流能对伴肾性高血压尿毒症患者的血压有一定的控制作用,可促进血红蛋白合成,但对透析后KT/V与PTH均无明显影响.Objective:To analyze the effects of hemodialysis combined with hemoperfusion on blood pressure,hemoglobin and urea clearance index(KT/V)in uremia patients with renal hypertension.Methods:A total of 82 patients with uremia and renal hypertension admitted to our hospital from April 2020 to March 2022 were selected as study objects.According to random number table method,they were divided into observation group(n=42,treated by hemodialysis combined with hemoperfusion)and control group(n=40,treated by hemodialysis only).The blood pressure and hemoglobin before and after dialysis,KT/V value after dialysis,parathyroid hormone(PTH)clearance rate and incidence of adverse reactions were compared between the two groups.Results:After dialysis,blood pressure decreased,and hemoglobin increased in the two groups,the blood pressure of the observation group changed greatly and the hemoglobin was higher than that of the control group,and the differences were statistically significant(P<0.05).There were no significant differences in KT/V value and PTH clearance rate after dialysis between the two groups(P>0.05).The incidence of adverse reactions in the observation group was significantly lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion:Hemodialysis combined with hemoperfusion can control blood pressure and promote hemoglobin synthesis in uremic patients with renal hypertension,but has no special effect on KT/Vand PTH.

关 键 词：血液透析 血液灌流 肾性高血压 尿毒症 血压 血红蛋白 尿素清除指数 

分 类 号：R692[医药卫生—泌尿科学]