盐酸左氧氟沙星注射液治疗细菌性感染的临床评价  

Clinical Study of Levofloxacin Hydrochloride iv. in Treatmert of Bacterial Infections

作　　者：傅颖君[1] 

机构地区：[1]江西医学院药理教研室,江西南昌330006

出　　处：《实用临床医学（江西）》2002年第4期57-60,共4页Practical Clinical Medicine

摘　　要：目的 :评价国产盐酸左氧氟沙星注射液治疗细菌性感染的有效性和安全性。方法 :采用多中心随机对照平行开放试验方法 ,以乳酸左氧氟沙星注射液为对照组 ,治疗中重度呼吸系统、泌尿系统感染患者 175例 ,其中试验组 87例 ,对照组 88例 ,试验药与对照药的用量用法均静注 2次 /d ,每次 10 0mg ,疗程 5～ 9d。结果 :试验组和对照组的临床有效率分别为 90 .8% ,94 .3% ;细菌清除率分别为 88.8%和 89.2 % ;药物不良反应发生率分别为 10 %和14 .4 % ,两组临床及细菌学疗效及不良反应发生率无差异 (P >0 .0 5 )。结论Objective:To evaluate the clinical effectiveness and safety of Levofloxacin Hydrochloride(LVLXH) made in China versus Levofloxacin Lactate(LVLXL)in treatment of bacterial infective disease.Methods: A randomized controlled clinical trial of LVLXH versus LVLXL was studied.A total of 175 patients with moderate to serious respiratory system or urinary system infections were included. There were 87 cases treated with LVLXH and 88 cases treated with LVLXL. The dose of LVLXH or LVLXL was 100 mg, bid for 5～9 days respectively. Results: The clinical efficacy rates of LVLXH and LVLXL were 90.8% and 94.3%; the eradication rate were 88.8% and 89.2%; the incidences of adverse effects in LVLXH and LVLXL groups were 10% and 14.4% respectively.There were no significant differences between the two groups( P >0.05).Conclusion: Levofloxacine hydvochloride iv.is very effective and safe in treating bacterial infections.

关 键 词：盐酸左氧氟沙星注射液 治疗 细菌性感染 临床评价 

分 类 号：R515[医药卫生—内科学] R978.19[医药卫生—临床医学]