可见光催化烯烃的三组分串联三氟甲基化/偕二氟烯丙基化  

Visible-Light Photoredox-Catalyzed Three-Component Tandem Trifluoromethylation/Gem-Difluoroallylation of Alkenes

作　　者：袁汶雯 黄焰根 孟卫东[1] YUAN Wenwen;HUANG Yangen;MENG Weidong(College of Chemistry and Chemical Engineering,Donghua University,Shanghai 201620,China)

机构地区：[1]东华大学化学与化工学院,上海201620

出　　处：《Journal of Donghua University(English Edition)》2024年第1期57-71,共15页东华大学学报（英文版）

基　　金：National Natural Science Foundation of China (No.2199121)。

摘　　要：描述了一种高效的可见光诱导富电子烯烃的三氟甲基化/偕二氟烯丙基化三组分串联反应。三氟甲基(—CF_(3))自由基由市售的三氟甲磺酸钠(CF_(3)SO_(2)Na)生成,依次与富电子烯烃和α-三氟甲基烯烃相匹配,最后通过β-F消除得到多氟烯烃。该方法的优点是反应条件温和,官能团耐受性好,底物范围广,反应效率高,为药物和天然产物衍生物的后期改性提供了更多可能。An efficient,redox-neutral and visible-light-induced three-component tandem trifluoromethylation/gem-difluoroallylation reaction of electron-rich alkenes is described.Trifluoromethyl(—CF_(3))radical is generated from commercially available sodium trifluorome-thanesulfinate(CF_(3)SO_(2)Na),which is matched with the electron-rich alkene andα-trifluoromethyl alkene in turn,and finally,the polyfluoroolefin is obtained byβ-F elimination.The advantages of this method are mild reaction conditions,excellent functional-group tolerance,broad substrate scope,and high reaction efficiency,which provides an opportunity for the late-stage modification of pharmaceuticals and natural product derivatives.

关 键 词：自由基加成 三氟甲基化 偕二氟烯丙基化 烯烃 

分 类 号：O622.1[理学—有机化学]