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作 者:王亚茹 全超 徐甜 刘暑霞 杨丽昭 张玲[1] 戴霞云 WANG Yaru;QUAN Chao;XU Tian;LIU Shuxia;YANG Lizhao;ZHANG Ling;DAI Xiayun(Wuhan University of Science and Technology,Wuhan,Hubei 430065,China;Wuhan Prevention and Treatment Center for Occupational Diseases,Wuhan,Hubei 430015,China)
机构地区:[1]武汉科技大学,湖北武汉430065 [2]武汉市职业病防治院,湖北武汉430015
出 处:《公共卫生与预防医学》2024年第2期25-29,共5页Journal of Public Health and Preventive Medicine
基 金:武汉市卫生健康科研基金资助项目(WG21Q01)。
摘 要:目的 分析交通警察尿液中23种金属和类金属与甲状腺功能指标之间的关联性。方法 采用横断面研究设计,通过对湖北省武汉市166名交通警察(122名外勤人员,44名内勤人员)进行职业健康检查,分析尿液中23种金属和类金属元素与血液中甲状腺功能指标的相关性。结果 经过错误发现率多重校正后,在多金属模型中,尿锰和尿铀水平与血液中甲状腺过氧化物酶抗体(thyroid peroxidase antibody, TPOAb)水平呈正相关关系(β=66.57,95%CI:2.92~130.22,P=0.040和β=62.43,95%CI:14.37~110.49,P=0.011),尿铀水平与血液中促甲状腺激素(thyroid stimulating hormone, TSH)水平呈正相关关系(β=6.20,95%CI:2.68~9.72,P=0.001),尿铀水平与血液中游离甲状腺素(free thyroxine, FT4)呈负相关关系(β=-2.03,95%CI:-3.67~-0.39,P=0.015),尿铅水平与血液中TSH水平呈负相关关系(β=-4.59,95%CI:-8.67~-0.51,P=0.027)。结论 锰暴露与血液中TPOAb水平升高有关,铀暴露与血液中TPOAb水平升高、TSH水平升高和FT4水平降低有关,铅暴露与血液中TSH水平降低有关,说明重金属对交通警察甲状腺的危害性应引起重视。Objective To investigate the correlation between 23 metals and metalloids elements in the urine and thyroid function indicators of traffic police.Methods A cross-sectional study was performed to assess the effects of 23 metals and metalloids elements in the urine on blood thyroid function indicators in 166 traffic policemen(122 field staff and 44 internal staff)in Wuhan,Hubei Province.Each subject received an occupational health examination.Results After multiple corrections for false detection rates,in the polymetallic model,the levels of urinary manganese and urinary uranium were positively correlated with the levels of thyroid peroxidase antibody(TPOAb)in the blood(β=66.57,95%CI:2.92-130.22,P=0.040 andβ=62.43,95%CI:14.37-110.49,P=0.011),and the level of urinary uranium was positively correlated with thyroid stimulating hormone(TSH)levels in the blood(β=6.20,95%CI:2.68-9.72,P=0.001).Urinary uranium level was negatively correlated with free thyroxine level in the blood(FT4)(β=-2.03,95%CI:(-3.67)-(-0.39),P=0.015),and urinary lead level was negatively correlated with blood TSH level(β=-4.59,95%CI:(-8.67)-(-0.51),P=0.027).Conclusion Manganese exposure is related to the increase of TPOAb level in blood,uranium exposure is related to the increase of TPOAb and TSH levels and the decrease of FT4 level in blood,and lead exposure is related to the decrease of TSH level in blood,suggesting that more attention should be paid to the effects of heavy metals on the thyroid of traffic police.
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