1111例高原地区健康体检人群Hp感染率、抗体分型及logistic回归分析  

Hp infection rate,antibody typing and logistic regression analysis of 1 111 physical examination people in plateau area

作　　者：崔莹 金宇 刘晓玲 龚梅 巫雯嘉 CUI Ying;JIN Yu;LIU Xiaoling;GONG Mei;WU Wenjia(Department of Laboratory Medicine,The 2nd Affiliated Hospital of Chengdu Medical College,Nuclear Industry 416 Hospital,Chengdu,Sichuan 610000,China)

机构地区：[1]成都医学院第二附属医院·核工业四一六医院检验科,四川成都610000

出　　处：《公共卫生与预防医学》2024年第2期53-56,共4页Journal of Public Health and Preventive Medicine

摘　　要：目的 探究1 111例高原地区健康体检人群幽门螺杆菌(Hp)感染率、抗体分型,并采用logistic回归分析Hp感染的危险因素。方法 以2022年1~12月1 111例高原地区健康体检人群为研究对象,统计Hp感染率、抗体分型,并采用logistic回归分析Hp感染发生的危险因素。结果 高原地区健康体检人群中Hp感率为62.47%(694/1 111),感染患者中I型Hp感染率75.50%(524/694),高于II型Hp感染24.50%(170/694),差异有统计学意义(χ^(2)=361.141,P<0.001)。CagA诊断Hp感染的AUC值大于抗体VacA、Ure阳性单独诊断(Z=6.740、7.608,P<0.001)。感染组中男性、经常食用腌制类或烧烤类食物、有慢性胃病史、家庭共同生活人数≥4个的人数比例高于未感染组(χ^(2)=4.418、8.708、16.565、32.583,P=0.036、0.003、<0.001、<0.001),经常食用大蒜的人数比例低于未感染组(χ^(2)=5.153,P=0.023)。经常食用腌制类或烧烤类食物[OR(95%CI)为2.038(1.049~3.961)]、有慢性胃病史[OR(95%CI)=1.706(1.132~2.569)]、家庭共同生活人数≥4个[OR(95%CI)=1.857(1.135~3.037)]是Hp感染发生的危险因素,经常食用大蒜[OR(95%CI)=0.559(0.346~0.903)]为保护因素(P=0.036、0.011、0.014、0.018)。结论 高原地区健康体检人群Hp感染率及抗体Ure阳性率较高,且慢性胃病史、经常使用腌制类或烧烤类食物等为Hp感染发生的危险因素。Objective To explore the Helicobacter pylori(Hp)infection rate and antibody typing of 1111 physical examination people in plateau area,and to analyze the risk factors of Hp infection by logistics regression analysis.Methods 1111 healthy people with physical examination in plateau area from January 2022 to December 2022 were selected as the research subjects.The Hp infection rate and antibody typing were calculated,and the risk factors of Hp infection were analyzed by logistics regression analysis.Results The Hp infection rate of physical examination people in plateau area was 62.47%(694/1111).The infection rate of type I Hp in infected patients was higher than that of typeⅡHp(75.50%vs 24.50%)(X^(2)=361.141,P<0.001).The AUC of CagA in the diagnosis of Hp infection was higher than that of antibody VacA or Ure positive diagnosis alone(Z=6.740,7.608,P<0.001).The proportions of people with male gender,often eating pickled or barbecued foods,history of chronic gastric disease and family members living together≥4 in infected group were higher than those in uninfected group(X^(2)=4.418,8.708,16.565,32.583,P=0.036,0.003,<0.001,<0.001)while the proportion of people with regular garlic consumption was lower than that in uninfected group(X^(2)=5.153,P=0.023).Often eating pickled or barbecued foods OR(95%CI)=2.038(1.049-3.961)],history of chronic gastric disease[OR(95%CI)=1.706(1.132-2.569)]and family members living together≥4[OR(95%CI)=1.857(1.135-3.037)]were risk factors of Hp infection,and regular garlic consumption[OR(95%CI)=0.559(0.346-0.903)]was a protective factor(P=0.036,0.011,0.014,0.018).Conclusion The Hp infection rate and antibody Ure positive rate are higher in physical examination people in plateau area,and chronic gastric disease history and often eating pickled or barbecued foods are risk factors of Hp infection.

关 键 词：高原地区 健康体检人群 幽门螺杆菌感染 抗体分型 LOGISTIC回归分析 

分 类 号：R181[医药卫生—流行病学]