2019—2022年陕西汉中地区急性肠道感染病毒病原谱分析  

Viral pathogen spectrum analysis of acute intestinal infection in Hanzhong in 2019-2022

作　　者：聂伟杰 王维 贺礼琴 NIE Weijie;WANG Wei;HE Liqin(Department of Gastroenterology,3201 Hospital Hanzhong,Hanzhong,Shaanxi 723000,China)

机构地区：[1]三二〇一医院消化内科,陕西汉中723000

出　　处：《公共卫生与预防医学》2024年第2期57-61,共5页Journal of Public Health and Preventive Medicine

摘　　要：目的 探究2019—2022年陕西汉中地区急性肠道感染病毒病原谱特征。方法 选取2019年1月至2022年12月三二○一医院门诊急性肠道感染患者粪便标本,经实时荧光定量PCR仪检测肠道病毒71型(EV-A71)、柯萨奇病毒16型(CV-A16)、CV-A10、CV-A6、CV-A2、CV-A4、CV-B3等常见肠道感染病毒进行检测并分析。结果 共收集了5 194例粪便样本,病毒核酸阳性标本检出率23.95%,检出率最高为EV-A71 9.82%,其次为CV-A16 4.58%、CV-A6 3.37%。不同年龄组常见肠道感染病毒阳性检出率比较差异有统计学意义(P<0.05),其中0~4岁组最高41.49%。不同性别阳性病毒检出率比较差异无统计学意义(P>0.05)。EV-A71无季节性,CV-A16、CV-A6检出高峰集中于夏、秋季。106份混合感染,感染率2.04%,其中以EV-A71和CV-A6混合感染最多。结论 2019—2022年汉中地区急性肠道感染病毒病原体为EV-A71、CV-A16、CV-A6,应增强对4岁及以下儿童的急性肠道感染病毒监测。Objective To explore the viral pathogen spectrum characteristics of acute intestinal infection in Hanzhong from 2019 to 2022.Methods Fecal samples from patients with acute intestinal infection in the outpatient clinic of 3201 Hospital from January 2019 to December 2022 were collected.Common enteroviruses such as enterovirus 71(EV-A71),coxsackievirus 16(CV-A16),CV-A10,CV-A6,CV-A2,CV-A4,and CV-B3 were detected and analyzed by real-time fluorescence quantitative PCR.Results A total of 5194 fecal samples were collected,and the positive rate of nucleic acid detection was 23.95%.In terms of the enteroviruses,the highest detection rate was 9.82%for EV-A71,followed by 4.58%for CV-A16 and 3.37%for CV-A6.The positive detection rate of common enteroviruses showed statistical difference among different age groups(P<0.05),with the highest detection rate of 41.49%in 0-4 years old group.There was no significant difference in the positive virus detection rate between different genders(P>0.05).EV-A71 infection showed no seasonal characteristics,whereas the detection of CV-A16 and CV-A6 infections was concentrated in summer and autumn.There were 106 cases of mixed infection,and the prevalence rate was 2.04%,with EV-A71 and CV-A6 mixed infections accounting for the majority of cases.Conclusion The main pathogens of acute intestinal infections in the Hanzhong area from 2019 to 2022 are EV-A71,CV-A16,and CV-A6.It is necessary to strengthen the monitoring of acute intestinal infections in children aged 4 years and below.

关 键 词：急性肠道感染 肠道病毒 病原谱 流行病学特征 

分 类 号：R181[医药卫生—流行病学]