基于社区健康体检人群幽门螺杆菌感染因素及免疫学分型研究  

Helicobacter pylori infection factors and immunological typing in community health examination population

作　　者：何丽[1] HE Li(Department of Family Medicine,Guangyuan First People′s Hospital,Guangyuan,Sichuan 628000,China)

机构地区：[1]四川省广元市第一人民医院全科医学科,四川广元628000

出　　处：《公共卫生与预防医学》2024年第2期83-86,共4页Journal of Public Health and Preventive Medicine

摘　　要：目的 调查分析社区健康体检人群幽门螺杆菌(helicobacter pylori,Hp)感染的危险因素及Hp感染者免疫学分型。方法 选取2022年7月至2023年4月在广元市第一人民医院进行健康体检的某社区居民,采用免疫印迹法检测Hp抗体并分型,采用二元logistic回归分析社区居民Hp感染危险因素,比较不同上消化道疾病及伴慢性疾病人群的免疫学分型结果。结果 2 475例健康体检人群Hp感染率为35.64%(882/2 475),其中Ⅰ型Hp抗体阳性率23.72%(587/2 475),Ⅱ型Hp抗体阳性率11.92%(295/2 475)。Hp感染率在性别、年龄、吸烟史和是否患糖尿病上存在显著性差异(P<0.05)。多因素logistic回归分析显示男性、年龄≥60岁及有饮酒史、糖尿病均是人群Hp感染的危险因素(P<0.05)。男性和伴冠心病的感染者Ⅰ型Hp抗体阳性率高于女性和不伴冠心病的感染者(P<0.05)。结论 该社区健康体检人群Hp感染率偏低,以I型为主,Hp感染受到性别、年龄、饮酒史及糖尿病的影响,Ⅰ型Hp抗体阳性人群中男性较多且冠心病患病风险可能更高,临床应把易感人群作为防治重点,采取针对性监测及诊疗措施。Objective To investigate and analyze the risk factors of Helicobacter pylori(Hp)infection and the immunological classification of Hp-infected people in community health examination population.Methods Among of the 2475 residents in a community who underwent health examination in Guangyuan First People′s Hospital were selected between July 2022 and April 2023.Western blotting was used to detect and type the Hp antibodies.The risk factors of Hp infection in the community residents were analyzed by binary logistic regression analysis,and the results of immunological typing were compared among patients with different upper digestive tract diseases and chronic diseases.Results The Hp infection rate among of the 2475 residents who underwent physical examination was 35.64%(882/2475),and the positive rates of type I Hp antibody and type II Hp antibody were 23.72%(587/2475)and 11.92%(295/2475),respectively.There were significant differences in Hp infection rates in gender,age,smoking history,and whether or not people had diabetes(P<0.05).Multivariate logistic regression analysis showed that male,age≥60 years old,drinking history and diabetes were risk factors of Hp infection in the community health examination population(P<0.05).The positive rate of type I Hp antibody in men and patients with coronary heart disease was higher than that in women and patients without coronary heart disease(P<0.05).Conclusion The infection rate of Hp among health examination population in this community is low,mainly type I.Hp infection is affected by gender,age,drinking history and diabetes.There are more males in the population with type I Hp antibody positivity,and the risk may be higher in patients with coronary heart disease.Clinically,it is necessary to take susceptible population as the focus of prevention and treatment,and take targeted monitoring and diagnosis and treatment measures.

关 键 词：社区 体检人群 幽门螺杆菌 感染率 免疫学分型 

分 类 号：R181[医药卫生—流行病学]