梅毒患者血清甲状腺功能和hs-CRP表达水平及其凝血功能分析  

Serum thyroid function,hs-CRP expression,and coagulation function in syphilis patients

作　　者：胡轩 李迁 何浩[3] HU Xuan;LI Qian;HE Hao(Department of Laboratory Medicine,Bazhong Central Hospital,Bazhong,Sichuan 636001,China;Department of Radiology,Bazhong Central Hospital,Bazhong,Sichuan 636001,China;Department of Infection,Bazhong Central Hospital,Bazhong,Sichuan 636001,China)

机构地区：[1]四川省巴中市中心医院检验科,四川巴中636001 [2]四川省巴中市中心医院放射科,四川巴中636001 [3]四川省巴中市中心医院感染科,四川巴中636001

出　　处：《公共卫生与预防医学》2024年第2期144-147,共4页Journal of Public Health and Preventive Medicine

摘　　要：目的 探究梅毒患者血清甲状腺功能和hs-CRP表达水平及其与凝血功能的关系。方法 选择巴中市中心医院2021年1月至2023年1月收治梅毒患者80例作为研究对象,设为观察组,另外选取80例健康体检者作为对照组,80例银屑病患者作为疾病对照组。比较甲状腺功能、hs-CRP、凝血功能,分析梅毒患者甲状腺功能、hs-CRP与凝血功能相关性,分析以上参数预测梅毒的效能。结果 观察组FT3、FT4、TSH、hs-CRP的值均高于对照组与疾病对照组(P<0.05)。观察组甲状腺功能异常与hs-CRP水平异常率均高于对照组与疾病对照组(P<0.05)。观察组PT、APTT、TT均高于对照组与疾病对照组(P<0.05)。观察组凝血功能异常率均高于对照组与疾病对照组(P<0.05)。一期梅毒FT3、FT4、TSH、hs-CRP、PT、APTT、TT均低于二期与三期,而二期上述参数均低于三期(P<0.05)。梅毒病情程度均与FT3、FT4、hs-CRP、APTT、TT呈正相关(P<0.05)。以上指标中FT3诊断梅毒效能较高。结论 梅毒患者存在甲状腺功能亢进现象,伴凝血功能紊乱以及hs-CRP异常增高,均与梅毒患者的病情存在一定关联性,联合预测梅毒患者的效能较好。Objective To investigate the serum levels of thyroid function and hs-CRP expression in patients with syphilis and their relationship with coagulation function.Methods A total of 80 syphilis patients admitted to Bazhong Central Hospital from January 2021 to January 2023 were selected as the study subjects and set as the observation group.In addition,80 healthy individuals were selected as the control group,and 80 psoriasis patients were selected as the disease control group.Thyroid function,hs-CRP and coagulation function among different groups were compared.The correlation between thyroid function,hs-CRP,and coagulation function in patients with syphilis was analyzed,and the effectiveness of these parameters in predicting syphilis was analyzed.Results The values of FT3,FT4,TSH and hs-CRP in the observation group were higher than those in the control group and the disease control group(P<0.05).The abnormal rates of thyroid function and hs-CRP level in the observation group were higher than those in the control group and the disease control group(P<0.05).PT,APTT,and TT of the observation group were higher than those of the control group and the disease control group(P<0.05).The abnormal rate of coagulation function in the observation group was higher than that in the control group and the disease control group(P<0.05).The levels of FT3,FT4,TSH,hs-CRP,PT,APTT,and TT in the first stage were lower than those in the second and third stages,while these parameters in the secondary stage were lower than those in the third stage(P<0.05).The severity of syphilis was positively correlated with FT3,FT4,hs-CRP,APTT,and TT(P<0.05).Among these indicators,FT3 was more effective in the diagnosis of syphilis.Conclusion Syphilis patients have hyperthyroidism,accompanied by coagulation dysfunction and abnormal increase in hs-CRP,which are all related to the condition of syphilis patients.The combined prediction of syphilis patients has high effectiveness.

关 键 词：梅毒 血清 甲状腺功能 凝血功能 

分 类 号：R181[医药卫生—流行病学]