A型塞内卡病毒序列元件与蛋白功能研究进展  

Research Advance in Sequence Elements and Protein Functions of Senecavirus A

作　　者：南福龙 孟海蓝 李紫薇 沙洲 尼博[2] 刘拂晓[1] NAN Fulong;MENG Hailan;LI Ziwei;SHA Zhou;NI Bo;LIU Fuxiao(College of Veterinary Medicine,Qingdao Agricultural University,Qingdao 266109,China;China Animal Health and Epidemiology Center,Qingdao 266032,China)

机构地区：[1]青岛农业大学动物医学院,山东青岛266109 [2]中国动物卫生与流行病学中心,山东青岛266032

出　　处：《中国兽医杂志》2024年第2期89-95,共7页Chinese Journal of Veterinary Medicine

基　　金：“十四五”国家重点研发计划(2021YFD1800300);青岛农业大学研究生创新计划项目(QNYCX23009)。

摘　　要：A型塞内卡病毒(SVA)是一种引起猪水疱性疾病的新发病毒。该病毒是小RNA病毒科、塞内卡病毒属的唯一成员。SVA基因组为单股、正链、不分节段的线性RNA,其中间为较长的编码区,共编码4种结构蛋白和8种非结构蛋白;两端分别为5′和3′非编码区,在病毒复制、启动蛋白表达以及影响病毒毒力等过程中起到了重要的作用。SVA的结构蛋白为VP1、VP2、VP3和VP4,主要参与病毒衣壳的形成;非结构蛋白则与病毒复制和免疫逃逸密切相关。作为一种新发病原体,关于SVA分子机制的研究尚未深入。本文系统地总结了SVA基因组结构和功能的研究进展,为SVA的深入研究,尤其是抗病毒制剂的研制提供参考依据。Senecavirus A(SVA)is a newly discovered virus causing vesicular diseases in pigs.This virus belongs to the Picornaviridae family and is the sole member of the Senecavirus genus.The SVA genome is a linear RNA with a positive-sense,non-segmented single strand.It contains a relatively long coding region encoding four structural proteins and eight non-structural proteins.The 5′and 3′untranslated regions at the ends play crucial roles in processes such as virus replication,initiation of protein expression,and affecting viral virulence.The structural proteins of SVA include VP1,VP2,VP3,and VP4,primarily involved in the formation of the virus capsid,while non-structural proteins are closely associated with virus replication and immune evasion.As a newly identified pathogen,the molecular mechanisms of SVA are not yet well understood.This article systematically reviews the research progress on the genomic structure and function of SVA,providing a reference for the in-depth study of SVA,especially for the development of antiviral agents.

关 键 词：A型塞内卡病毒 基因 蛋白 结构 功能 

分 类 号：S855.3[农业科学—临床兽医学]