老年冠心病患者衰弱的危险因素与全身性炎症反应指数的相关性分析  

Risk factors of asthenia and correlation between them and systemic inflammatory response indexes in elderly patients with coronary heart disease

作　　者：焦莉莉 周金锋 Jiao Lili;Zhou Jinfeng(Department of Cardiovascular Medicine,Fuyang Hospital,Anhui Medical University,Fuyang 236200,China;不详)

机构地区：[1]安徽医科大学附属阜阳医院心血管内科,阜阳236200

出　　处：《中国循证心血管医学杂志》2023年第12期1330-1333,共4页Chinese Journal of Evidence-Based Cardiovascular Medicine

基　　金：安徽医科大学青年科学基金(2021xkj078)。

摘　　要：目的探讨老年冠状动脉粥样硬化性心脏病(冠心病)患者衰弱的危险因素与全身性炎症反应指数(SIRI)的相关性。方法回顾性分析175例老年冠心病患者,采用Fried量表进行衰弱评估,根据评估将患者分为衰弱组和非衰弱组,分析老年冠心病患者衰弱的相关影响因素,采用多因素Logistic回归分析衰弱的危险因素。绘制受试者工作特征(ROC)曲线分析SIRI对老年冠心病患者衰弱的预测界值,确定曲线下面积(AUC)、最佳界值。结果研究共纳入175例老年冠心病患者中,衰弱组103例(58.9%);非衰弱组72例(41.1%);单因素分析结果显示衰弱组与非衰弱组在脑卒中病、慢性阻塞性肺病(COPD)、心功能不全、年龄、收缩压、单核细胞、SIRI上均存在显著差异(P<0.05);二分类Logistic回归分析结果显示COPD、年龄、收缩压、SIRI是老年冠心病患者发生衰弱的独立危险因素;SIRI预测衰弱的AUC为0.623(SE=0.043,P<0.05,95%CI:0.538~0.707),最佳界值为1.000。结论COPD、年龄、收缩压、SIRI增加了老年冠心病患者衰弱的风险,SIRI对老年冠心病患者衰弱的诊断具有一定预测价值。Objective To discuss the risk factors for asthenia and correlation between them and systemic inflammatory response indexes(SIRI)in elderly patients with coronary heart disease(CHD).Methods Elderly CHD patients(n=175)were retrospectively analyzed,Fried scale was used for reviewing asthenia,and all patients were divided,according to reviewing results,into asthenia group and non-asthenia group.The influence factors related to asthenia were analysis,and risk factors for asthenia were analyzed by using multi-factor Logistic regression analysis.The predictive cutoff value of SIRI to asthenia was analyzed,and AUC and the optimal cutoff value were determined by using ROC curve.Results There were totally 175 elderly CHD patients chosen in this study,including 103(58.9%)in asthenia group and 72(41.1%)in non-asthenia group.The results of single-factor analysis showed that there were significant differences in stroke,chronic obstructive pulmonary disease(COPD),cardiac insufficiency,age,systolic blood pressure(SBP),monocytes and SIRI between 2 groups(P<0.05).The results of binary Logistic regression analysis showed that COPD,age,SBP and SIRI were independent risk factors for asthenia in elderly CHD patients.AUC of SIRI in predicting asthenia was 0.623(SE=0.043,P<0.05,95%CI:0.538~0.707)and the optimal cutoff value was 1000.Conclusion COPD,age,SBP and SIRI can increase the risk of asthenia,and SIRI has some predictive value to asthenia diagnosis in elderly CHD patients.

关 键 词：冠心病 衰弱 危险因素 全身炎症反应指数 

分 类 号：R514.4[医药卫生—内科学]