选择性动脉灌注化疗栓塞联合全身化疗治疗晚期食管癌的临床研究  

Clinical study of selective arterial infusion chemoembolization combined with systemic chemotherapy in patients with advanced esophageal cancer

作　　者：郝华鑫 戚馨月 刘天隆 宋荣乔 HAO Huaxin;QI Xinyue;LIU Tianlong;SONG Rongqiao(Department of Interventional Medicine,the Third Affiliated Hospital of Gansu University of Traditional Chinese Medicine/the First People′s Hospital of Baiyin,Baiyin,Gansu 730900,China)

机构地区：[1]甘肃省中医药大学第三附属医院/白银市第一人民医院介入医学科,甘肃白银730900

出　　处：《现代医药卫生》2024年第5期766-770,共5页Journal of Modern Medicine & Health

基　　金：甘肃省白银市第一人民医院院内科研培育基金项目(2021PY-05)。

摘　　要：目的评价选择性动脉灌注化疗栓塞术(SAPCT)联合全身化疗(SC)治疗晚期食管癌的短期及远期疗效及安全性。方法选取2017年6月至2019年6月该院收治的112例晚期食管癌患者,将其分为试验组(57例)和对照组(55例)。试验组患者给予SAPCT联合SC(5-氟尿嘧啶/顺铂方案)治疗,对照组患者给予SC(5-氟尿嘧啶/顺铂方案)治疗,2组患者均化疗2个周期。对比2组患者短期、远期临床疗效及不良反应发生情况。结果化疗1周期后,试验组患者吞咽困难缓解程度明显优于对照组,差异有统计学意义(P<0.05)。化疗2周期后,试验组患者部分缓解率和进展率优于对照组,差异均有统计学意义(P<0.05);试验组患者远期疗效PFS和OS优于对照组,差异均有统计学意义(P<0.001)。结论SAPCT联合SC治疗晚期食管癌不仅可以明显缓解患者吞咽困难症状,而且可显著改善患者的预后。Objective To evaluate the long-term efficacy and safety of selective arterial perfusion chemoembolization technique(SAPCT)combined with systemic chemotherapy(SC)in the treatment of advanced esophageal cancer.Methods A total of 112 patients with advanced esophageal cancer admitted to this hospital from June 2017 to June 2019 were divided into the experimental group(57 cases)and the control group(55 cases).The experimental group was given SAPCT combined with SC(5-fluorouracil/cisplatin),while the control group was given SC(5-fluorouracil/cisplatin).All patients in the two groups received two cycles of chemotherapy.The short-term and long-term clinical efficacy and the occurrence of adverse reactions were compared between the two groups.Results After one cycle of chemotherapy,the relief of dysphagia in the experimental group was significantly better than that in the control group(P<0.05).After two cycles of chemotherapy,there were statistically significant differences in partial remission rate and progression rate between the two groups(P<0.05).The long-term curative effects of PFS and OS in the experimental group were better than those in the control group,and the differences were statistically significant(P<0.05).Conclusion SAPCT combined with SC in the treatment of advan ced esophageal cancer can not only significantly relieve dysphagia symptoms,but also significantly improve the prognosis of patients.

关 键 词：食管癌 选择性动脉栓塞 化疗 联合治疗 吞咽困难 晚期 

分 类 号：R659[医药卫生—外科学]