基于中医传承辅助平台探讨国医大师治疗癌因性疲乏用药规律  

Discussion on Medication Rules of Chinese Medical Masters in Treating Cancerrelated Fatigue Based on Traditional Chinese Medicine Inheritance Support System

作　　者：赵越 王文萍[2] 李晓斌[2] 王华伟[2] 曹莹 ZHAO Yue;WANG Wenping;LI Xiaobin;WANG Huawei;CAO Ying(Liaoning University of Traditional Chinese Medicine,Shenyang 110847,Liaoning,China;Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,Liaoning,China)

机构地区：[1]辽宁中医药大学,辽宁沈阳110847 [2]辽宁中医药大学附属医院,辽宁沈阳110032

出　　处：《辽宁中医药大学学报》2024年第1期124-128,共5页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：国家重点研发计划项目(2018YFC1311600);辽宁省“兴辽英才计划”基金项目(XLYC1802008);辽宁省名老中医工作室项目。

摘　　要：目的 探讨国医大师治疗癌因性疲乏的用药规律。方法 收集三大数据库(知网、万方、维普)、古今医案云平台、公开出版的中国医大师治疗癌因性疲乏的成功案例,筛选、整理处方数据后录入中医传承辅助平台(V2.5)分析用药规律。结果 共纳入15位国医大师的87则医案,涉及228味中药,药物四气分布以温热、寒凉为主,且二者比例相当;五味分布以甘、苦、辛为主;归经频次靠前的是脾、肝,肺、胃、肾、心稍居其后;使用频次最多的是补虚药,且以补气药为主,其次是清热药;使用频次前10的药物为黄芪、白术、炙甘草、茯苓、陈皮、白花蛇舌草、当归、女贞子、麦芽、党参,常用对药、角药有“黄芪-白术-茯苓”“陈皮-黄芪-白术”“白花蛇舌草-黄芪”“黄芪-当归”等;基于复杂系统熵聚类得到5组新方。结论 国医大师治疗癌因性疲乏区别传统虚劳疾病的治疗原则,从“虚-毒-瘀”的肿瘤病机出发,辛温补虚之药与苦寒解毒之药并用,巧配甘味药缓补机体,重视健脾疏肝,兼顾肺、肾、心三脏,以治气为题眼展开解题思路。Objective To explore the medication rules of Chinese medicine masters in treating cancer-related fatigue.Methods Successful cases of cancer-related fatigue treated by Chinese medical masters were collected from three major databases,ancient and modern medical case cloud platforms,and published works.After screening and sorting out the prescription data,they were entered into the Traditional Chinese Medicine Inheritance Support System(V2.5)to analyze the medication rules.Results A total of 87 medical cases of 15 national medical masters were included,involving 228 traditional Chinese medicines.The distribution of the four Qi of the drugs was mainly warm,hot and cold,and the proportion of the two was equal.The distribution of five flavors is mainly sweet,bitter and pungent;meridian frequency front is the spleen,liver,lung,stomach,kidney,heart slightly behind;the most frequently used is tonic medicine,and mainly tonic medicine,followed by heat-clearing medicine;use frequency of the top 10 drugs for Huangqi(Astragali Radix),Baizhu(Atractylodis Macrocephalae Rhizoma),Zhigancao(Glycyrrhizae Radix Et Rhizoma Praeparata Cum Melle),Fuling(Poria),Chenpi(Citri Reticulatae Pericarpium),Baihuasheshecao(Hedyotis Diffusa),Danggui(Angelicae Sinensis Radix),Nuzhenzi(Ligustri Lucidi Fructus),Maiya(Hordei Fructus Germinatus),Dangshen(Codonopsis Radix),commonly used for drugs,horn medicine have“Huangqi(Astragali Radix)-Baizhu(Atractylodis Macrocephalae Rhizoma)-Fuling(Poria)”“Chenpi(Citri Reticulatae Pericarpium)-Huangqi(Astragali Radix)-Baizhu(Atractylodis Macrocephalae Rhizoma)”“Baihuasheshecao(Hedyotis Diffusa)-Huangqi(Astragali Radix)”“Huangqi(Astragali Radix)-Danggui(Angelicae Sinensis Radix)”;five groups of new formulae were obtained based on complex system entropy clustering.Conclusion The treatment principle of cancer-related fatigue is different from that of traditional consumptive diseases.Starting from the tumor pathogenesis of“deficiency-toxin-stasis”,Chinese medicine masters use pungent and warm drug

关 键 词：癌因性疲乏 CRF 用药规律 中医传承辅助平台 

分 类 号：R273[医药卫生—中西医结合]