健脾渗湿解毒汤治疗湿浊中阻型高尿酸血症的临床效果  

Clinical effect of Jianpi Xiaoshi Jiedu Decoction on dampness turbidityblocking hyperuricemia

作　　者：吴小翠[1] 杨文奎[1] 邱晓堂[1] 叶文静 WU Xiaocui;YANG Wenkui;QIU Xiaotang;YE Wenjing(Department of Endocrinology,Hainan Traditional Chinese Medicine Hospital,Hainan Province,Haikou 570203,China)

机构地区：[1]海南省中医院内分泌科,海南海口570203

出　　处：《中国医药导报》2024年第1期87-91,共5页China Medical Herald

基　　金：国家中医药管理局全国老中医药专家学术经验继承工作项目(国中医药人教函〔2022〕76号);国家中医药管理局高水平中医药重点学科中医老年医学建设项目(琼卫中医函〔2023〕3号);海南省重点研发项目(ZDYF2020161);海南省重大科技计划项目(ZDKJ2021034)。

摘　　要：目的探讨健脾渗湿解毒汤治疗湿浊中阻型高尿酸血症的临床效果。方法选取2021年2月至2022年12月于海南省中医院内分泌科门诊或病房诊治的高尿酸血症患者106例,按随机数字表法分研究组(54例)和对照组(52例)。研究组服用健脾渗湿解毒汤,对照组口服苯溴马隆片(50 mg/次,1次/d)。两组均治疗3个月。观察两组治疗前后血尿酸(UA)、胆固醇、甘油三酯(TG)、低密度脂蛋白(LDL-C)、空腹血糖(FPG)、中医证候积分及安全性分析。结果治疗后,两组尿酸低于治疗前,差异有统计学意义(P<0.05);两组尿酸比较,差异无统计学意义(P>0.05)。治疗后,研究组FPG、TC低于治疗前,且低于对照组,差异有统计学意义(P<0.05)。治疗后,两组TG、LDL-C、肌酐、谷草转氨酶、谷丙转氨酶与治疗前比较,差异无统计学意义(P>0.05);两组TG、LDL-C比较,差异无统计学意义(P>0.05)。治疗后,两组症候总积分低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05)。研究组不良反应发生率与复发率低于对照组,差异无统计学意义(P>0.05)。结论健脾渗湿解毒汤治疗湿浊中阻型高尿酸血症,能显著改善患者的中医临床症候,较好地降低尿酸水平,且安全性较高,具有较高的临床应用价值。Objective To investigate the clinical effect of Jianpi Xiaoshi Jiedu Decoction on dampness turbidity-blocking hyperuricemia.Methods A total of 106 hyperuricemia patients diagnosed and treated in the outpatient department or ward of the Department of Endocrinology of Hainan Traditional Chinese Medicine Hospital from February 2021 to December 2022 were selected and divided into study group(54 cases)and control group(52 cases)according to random number table method.The study group took Jianpi Xiaoshi Jiedu Decoction,and the control group took Benzbromarone Tablets orally(50 mg/time,once/day).Both groups were treated for three months.Blood uric acid,cholesterol(TC),triglyceride(TG),low density lipoprotein(LDL-C),fasting blood glucose(FPG),traditional Chinese medicine syndrome score,and safety analysis were observed before and after treatment.Results After treatment,the uric acid of the two groups were lower than those before treatment,and the differences were statistically significant(P<0.05).There was no significant difference in uric acid between the two groups(P>0.05).After treatment,FPG and TC in study group were lower than those before treatment and lower than control group,the differences were statistically significant(P<0.05).After treatment,there was no significant difference in TG,LDL-C,creatinine,alanine transaminases,and aspartate transaminase between two groups compared with before treatment(P>0.05).There was no significant difference in TG and LDL-C,creatinine,aspartate transaminase,and alanine transaminas e between the two groups(P>0.05).After treatment,the total score of symptoms in the two groups were lower than those before treatment,and the study group was lower than the control group,and the differences were statistically significant(P<0.05).The incidence of adverse events and recurrence in the study group were lower than those in the control group,and the differences were not statistically significant(P>0.05).Conclusion Jianpi Xiaoshi Jiedu Decoction in the treatment of dampness turbidity-blocking

关 键 词：健脾渗湿解毒汤 高尿酸血症 湿浊中阻型 血尿酸水平 

分 类 号：R256[医药卫生—中医内科学]