连花清瘟胶囊联合西药治疗社区获得性肺炎临床研究  

Clinical Study on Lianhua Qingwen Capsules Combined with Western Medicine for Community Acquired Pneumonia

作　　者：王坤 王银慧 WANG Kun;WANG Yinhui(Chun'an County First People's Hospital,Chun'an Zhejiang 311700,China)

机构地区：[1]淳安县第一人民医院,浙江淳安311700

出　　处：《新中医》2024年第2期68-73,共6页New Chinese Medicine

摘　　要：目的:观察连花清瘟胶囊联合西药治疗社区获得性肺炎(CAP)痰热壅肺证的临床疗效。方法:选取98例CAP痰热壅肺证患者,以随机数字表法分为治疗组49例与对照组49例。剔除治疗组1例,对照组3例,最终纳入研究治疗组48例、对照组46例。对照组给予阿奇霉素片联合注射用头孢曲松钠治疗,治疗组在对照组基础上给予连花清瘟胶囊治疗。2组均治疗7 d。比较2组临床疗效、中医证候评分、炎症指标[超敏C-反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]及免疫指标[免疫球蛋白(Ig)A、IgG、IgM]水平。结果:治疗后,治疗组总有效率95.83%,高于对照组82.61%(P<0.05)。2组咳嗽、痰多、痰白干黏或痰黄、胸痛、发热、口渴、尿黄、大便秘结、腹胀评分均较治疗前降低(P<0.05),治疗组上述9项中医证候评分均低于对照组(P<0.05)。2组血清hs-CRP、IL-6、TNF-α水平均较治疗前降低(P<0.05),治疗组上述3项指标水平均低于对照组(P<0.05)。2组血清IgA、IgG、IgM水平均较治疗前升高(P<0.05),治疗组上述3项指标水平均高于对照组(P<0.05)。结论:连花清瘟胶囊联合西药治疗CAP痰热壅肺证疗效显著,可减轻临床症状,抑制炎症反应,增强免疫功能。Objective:To observe the clinical effect of Lianhua Qingwen Capsules combined with western medicine for community acquired pneumonia(CAP) with phlegm-heat obstructing the lung syndrome.Methods:A total of 98 cases of CAP patients with phlegm-heat obstructing the lung syndrome were selected and divided into the treatment group and the control group according to the random number table method,with 49 cases in each group;1 case was excluded from the treatment group,and 3 cases were excluded from the control group;finally 48 cases in the treatment group and 46 cases in the control group were included.The control group was treated with Azithromycin Tablets combined with Ceftriaxone Sodium for Injection,and the treatment group was additionally treated with Lianhua Qingwen Capsules based on the treatment of the control group.Both groups were treated for 7 days.Clinical effects,traditional Chinese medicine(TCM) syndrome scores,and levels of inflammatory indicators [highsensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6),and tumor necrosis factor-α(TNF-α)] and immune indicators [Immunoglobulin(Ig) A,IgG,and IgM] were compared between the two groups.Results:After treatment,the total effective rate was 95.83% in the treatment group,higher than that of82.61% in the control group(P<0.05).The scores of cough,profuse phlegm,dry sticky white phlegm or yellow phlegm,chest pain,fever,thirst,yellow urine,dry stool,and fullness of stomach cavity in the two groups were decreased when compared with those before treatment(P<0.05),and the above nine TCM syndrome scores in the treatment group were lower than those in the control group(P<0.05).The levels of hs-CRP,IL-6,and TNF-α in the two groups were decreased when compared with those before treatment(P<0.05),and the above three levels in the treatment group were lower than those in the control group(P<0.05).The levels of IgA,IgG,and IgM in serum in the two groups were increased when compared with those before treatment(P<0.05),and the above three levels in the treatment group w

关 键 词：社区获得性肺炎 痰热壅肺证 连花清瘟胶囊 阿奇霉素片 注射用头孢曲松钠 炎症指标 免疫功能 

分 类 号：R563.19[医药卫生—呼吸系统]