骨松宝颗粒联合西药治疗女性骨质疏松症临床研究  

Clinical Study on Gusongbao Granules Combined with Western Medicine for Female Osteoporosis

作　　者：申钰 郑春伟 薛鸾[2] SHEN Yu;ZHENG Chunwei;XUE Luan(Shanghai Yangpu Hospital of Traditional Chinese Medicine,Shanghai 200080,China;Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200437,China)

机构地区：[1]上海市杨浦区中医医院,上海200080 [2]上海中医药大学附属岳阳中西医结合医院,上海200437

出　　处：《新中医》2024年第2期95-99,共5页New Chinese Medicine

基　　金：上海市进一步加快中医药事业发展三年行动计划[ZY(2018-2020)-FWTX-7001]。

摘　　要：目的:观察骨松宝颗粒联合西药治疗女性骨质疏松症(OP)的临床疗效。方法:选取100例女性OP患者,根据治疗方式的不同将其分为对照组与观察组,每组50例。对照组给予西药(盐酸雷洛昔芬片、碳酸钙维D_(3)元素片、维生素D滴剂)治疗,观察组在对照组基础上给予骨松宝颗粒治疗,2组均治疗3个月。比较2组临床疗效,血清碱性磷酸酶(ALP)、I型前胶原氨基端前肽(PINP)、骨钙素(OST)、骨特异性碱性磷酸酶(BAP)、骨形态发生蛋白-2 (BMP-2)、微小RNA-133a (miR-133a)水平,以及L_(2~4)、股骨大转子、股骨颈骨密度。结果:治疗后,观察组总有效率96.00%,高于对照组80.00%(P<0.05)。2组血清ALP、PINP、BMP-2水平均较治疗前升高(P<0.05),血清OST、BAP、miR-133a水平均较治疗前降低(P<0.05);观察组血清ALP、PINP、BMP-2水平均高于对照组(P<0.05),血清OST、BAP、miR-133a水平均低于对照组(P<0.05)。2组L_(2~4)、股骨大转子、股骨颈骨密度均较治疗前升高(P<0.05),观察组股骨大转子、股骨颈骨密度均高于对照组(P<0.05)。2组L_(2~4)骨密度比较,差异无统计学意义(P>0.05)。结论:骨松宝颗粒联合西药治疗女性OP临床疗效较好,可有效改善骨代谢,提高骨密度,作用机制可能与调节血清BMP-2、miR-133a水平有关。Objective:To observe the clinical effect of the therapy of Gusongbao Granules combined with western medicine on female osteoporosis (OP).Methods:A total of 100 cases of female OP patients were selected and divided into the control group and the observation group according to different treatment methods,with 50 cases in each group.The control group was treated with western medicine (Raloxifene Hydrochloride Tablets,Calcium Carbonate Vitamin D_3Tablets,Vitamin D Drops),and the observation group was additionally treated with Gusongbao Granules based on the treatment of the control group.Both groups were treated for 3 months.The clinical effects,the levels of serum alkaline phosphatase (ALP),type I procollagen N-terminal propeptide (PINP),osteocalcin (OST),bone-specific alkaline phosphatase(BAP),bone morphogenetic protein-2 (BMP-2) and MicroRNA-133a (miR-133a),and the bone mineral density (BMD) of L_(2-4),femoral greater trochanter and femoral neck were compared between the two groups.Results:After treatment,the total effective rate was 96.00%in the observation group,higher than that of 80.00%in the control group (P<0.05).The levels of serum ALP,PINP,and BMP-2 in the two groups were increased when compared with those before treatment (P<0.05),and the levels of serum OST,BAP,and miR-133a were decreased when compared with those before treatment (P<0.05);the levels of serum ALP,PINP and BMP-2 in the observation group were higher than those in the control group (P<0.05),and the levels of serum OST,BAP and miR-133a were lower than those in the control group (P<0.05).The BMD of the L_(2-4),greater trochanter and neck of femur in both groups were higher than those before treatment (P<0.05),and the BMD of the greater trochanter and femur neck in the observation group was respectively higher than that in the control group (P<0.05).There was no significant difference in the comparison of the BMD of L_(2-4)between the two groups (P>0.05).Conclusion:The therapy of Gusongbao Granules combined with western medicine has a good clin

关 键 词：骨质疏松症 女性 骨松宝颗粒 骨代谢 骨密度 骨形态发生蛋白-2 微小RNA-133a 

分 类 号：R589.5[医药卫生—内分泌]